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Nanobody-based IgG simultaneously inhibit the allergenic and enzymatic activity of the dominant honeybee venom allergen.

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Title: Nanobody-based IgG simultaneously inhibit the allergenic and enzymatic activity of the dominant honeybee venom allergen.
Authors: Aagaard JB; Department of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark., Gandini R; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark., Ballegaard AR; Department of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark., Jensen BK; Department of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark., Dorn B; Department of Dermatology and Allergology, Justus Liebig University Giessen, Giessen, Germany., Larsen AVB; Department of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark., Lenstrup A; Department of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark., Sønderholm M; Department of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark., Miehe M; Department of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark., Pfützner W; Department of Dermatology and Allergology, Clinical & Experimental Allergology, Philipps University Marburg, Marburg, Germany., Jakob T; Department of Dermatology and Allergology, Justus Liebig University Giessen, Giessen, Germany. thilo.jakob@derma.med.uni-giessen.de., Andersen GR; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark. gra@mbg.au.dk., Möbs C; Department of Dermatology and Allergology, Clinical & Experimental Allergology, Philipps University Marburg, Marburg, Germany. moebs@med.uni-marburg.de., Spillner E; Department of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark. e.spillner@bce.au.dk.
Source: Nature communications [Nat Commun] 2026 Feb 17; Vol. 17 (1), pp. 1814. Date of Electronic Publication: 2026 Feb 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Nanobody-based IgG simultaneously inhibit the allergenic and enzymatic activity of the dominant honeybee venom allergen.
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  Data: <searchLink fieldCode="AU" term="%22Aagaard+JB%22">Aagaard JB</searchLink>; Department of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Gandini+R%22">Gandini R</searchLink>; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Ballegaard+AR%22">Ballegaard AR</searchLink>; Department of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Jensen+BK%22">Jensen BK</searchLink>; Department of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Dorn+B%22">Dorn B</searchLink>; Department of Dermatology and Allergology, Justus Liebig University Giessen, Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Larsen+AVB%22">Larsen AVB</searchLink>; Department of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Lenstrup+A%22">Lenstrup A</searchLink>; Department of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Sønderholm+M%22">Sønderholm M</searchLink>; Department of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Miehe+M%22">Miehe M</searchLink>; Department of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Pfützner+W%22">Pfützner W</searchLink>; Department of Dermatology and Allergology, Clinical & Experimental Allergology, Philipps University Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Jakob+T%22">Jakob T</searchLink>; Department of Dermatology and Allergology, Justus Liebig University Giessen, Giessen, Germany. thilo.jakob@derma.med.uni-giessen.de.<br /><searchLink fieldCode="AU" term="%22Andersen+GR%22">Andersen GR</searchLink>; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark. gra@mbg.au.dk.<br /><searchLink fieldCode="AU" term="%22Möbs+C%22">Möbs C</searchLink>; Department of Dermatology and Allergology, Clinical & Experimental Allergology, Philipps University Marburg, Marburg, Germany. moebs@med.uni-marburg.de.<br /><searchLink fieldCode="AU" term="%22Spillner+E%22">Spillner E</searchLink>; Department of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark. e.spillner@bce.au.dk.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Feb 17; Vol. 17 (1), pp. 1814. <i>Date of Electronic Publication: </i>2026 Feb 17.
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