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Decoding the Integrated Stress Response of Pancreatic Cancer: Identifying a Serine-dependent Tumor Subset Under Metabolic Relationships With CAFs.

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Title: Decoding the Integrated Stress Response of Pancreatic Cancer: Identifying a Serine-dependent Tumor Subset Under Metabolic Relationships With CAFs.
Authors: Shin S; Cancer Research Center of Toulouse (CRCT), INSERM U1037, ERL5294 CNRS, University of Toulouse, Toulouse, France.; Equipe Labellisée Ligue Contre le Cancer., Liauzun M; Cancer Research Center of Toulouse (CRCT), INSERM U1037, ERL5294 CNRS, University of Toulouse, Toulouse, France.; Equipe Labellisée Ligue Contre le Cancer., Solorzano J; Cancer Research Center of Toulouse (CRCT), INSERM U1037, ERL5294 CNRS, University of Toulouse, Toulouse, France.; Equipe Labellisée Ligue Contre le Cancer., Bras ML; Cancer Research Center of Toulouse (CRCT), INSERM U1037, ERL5294 CNRS, University of Toulouse, Toulouse, France.; Equipe Labellisée Ligue Contre le Cancer., Jean C; Cancer Research Center of Toulouse (CRCT), INSERM U1037, ERL5294 CNRS, University of Toulouse, Toulouse, France.; Equipe Labellisée Ligue Contre le Cancer., Fourneaux B; Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, ICM, Université De Montpellier, Montpellier, France., Dore M; Cancer Research Center of Toulouse (CRCT), INSERM U1037, ERL5294 CNRS, University of Toulouse, Toulouse, France.; Equipe Labellisée Ligue Contre le Cancer., Fevrier L; Cancer Research Center of Toulouse (CRCT), INSERM U1037, ERL5294 CNRS, University of Toulouse, Toulouse, France.; Equipe Labellisée Ligue Contre le Cancer., Belhabib I; Cancer Research Center of Toulouse (CRCT), INSERM U1037, ERL5294 CNRS, University of Toulouse, Toulouse, France.; Equipe Labellisée Ligue Contre le Cancer., Brunel A; Cancer Research Center of Toulouse (CRCT), INSERM U1037, ERL5294 CNRS, University of Toulouse, Toulouse, France.; Equipe Labellisée Ligue Contre le Cancer., Neuzillet C; Medical Oncology Department Curie Institute, Versailles Saint-Quentin University, Saint-Cloud, France., Larroque M; Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, ICM, Université De Montpellier, Montpellier, France., Joffre C; Cancer Research Center of Toulouse (CRCT), INSERM U1037, ERL5294 CNRS, University of Toulouse, Toulouse, France., Rocchi S; Centre Méditerranéen de Médecine Moléculaire, INSERM U1065, Université Cote d'Azur, Nice, France., Fraunhoffer N; Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Marseille, France., Perraud A; Department of Digestive Surgery, Faculty of Medicine, University Hospital of Limoges and INSERM U1308 - CAPTuR, University of Limoges, Limoges, France., Mathonnet M; Department of Digestive Surgery, Faculty of Medicine, University Hospital of Limoges and INSERM U1308 - CAPTuR, University of Limoges, Limoges, France., Pancaldi V; Cancer Research Center of Toulouse (CRCT), INSERM U1037, ERL5294 CNRS, University of Toulouse, Toulouse, France., Linares L; Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, ICM, Université De Montpellier, Montpellier, France., Iovanna J; Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Marseille, France., Dusetti N; Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Marseille, France., Larsson O; Department of Oncology-Pathology Karolinska Institutet, Stockholm, Sweden., Nicolle R; Centre de Recherche sur l'Inflammation (CRI), INSERM, U1149, CNRS, ERL 8252, Université Paris Cité, Paris, France., Pyronnet S; Cancer Research Center of Toulouse (CRCT), INSERM U1037, ERL5294 CNRS, University of Toulouse, Toulouse, France.; Laboratoire d'excellence LABEX TOUCAN, Toulouse, France., Bousquet C; Cancer Research Center of Toulouse (CRCT), INSERM U1037, ERL5294 CNRS, University of Toulouse, Toulouse, France.; Equipe Labellisée Ligue Contre le Cancer., Martineau Y; Cancer Research Center of Toulouse (CRCT), INSERM U1037, ERL5294 CNRS, University of Toulouse, Toulouse, France.; Equipe Labellisée Ligue Contre le Cancer.
Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2026 Mar; Vol. 13 (18), pp. e15740. Date of Electronic Publication: 2026 Feb 17.
Publication Type: Journal Article
Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:2198-3844
DOI:10.1002/advs.202515740