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Design of a Targeted Covalent Probe to Interrogate the DNA Polymerase Activity of Polθ.

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Title: Design of a Targeted Covalent Probe to Interrogate the DNA Polymerase Activity of Polθ.
Authors: Bubenik M; Repare Therapeutics, 7171 Frederick-Banting, Building 2, Montréal, Québec H4S 1Z9, Canada., Mader P; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario M5G 1X5, Canada., Orlicky S; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario M5G 1X5, Canada., Perryman AL; Repare Therapeutics, 7171 Frederick-Banting, Building 2, Montréal, Québec H4S 1Z9, Canada., Hamel M; Repare Therapeutics, 7171 Frederick-Banting, Building 2, Montréal, Québec H4S 1Z9, Canada., Godbout C; Repare Therapeutics, 7171 Frederick-Banting, Building 2, Montréal, Québec H4S 1Z9, Canada., Falgueyret JP; Repare Therapeutics, 7171 Frederick-Banting, Building 2, Montréal, Québec H4S 1Z9, Canada., Kurinov I; Department of Chemistry and Chemical Biology, Cornell University, NE-CAT, Argonne, Illinois 60439, United States., Wong C; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario M5G 1X5, Canada., Gingras AC; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario M5G 1X5, Canada., Mamane Y; Repare Therapeutics, 7171 Frederick-Banting, Building 2, Montréal, Québec H4S 1Z9, Canada., Zinda M; Repare Therapeutics, 101 Main Street, Suite 1650, Cambridge, Massachusetts 02142, United States., Morris SJ; Repare Therapeutics, 7171 Frederick-Banting, Building 2, Montréal, Québec H4S 1Z9, Canada., Gallant M; Repare Therapeutics, 7171 Frederick-Banting, Building 2, Montréal, Québec H4S 1Z9, Canada., Sfeir A; Molecular Biology Program, Sloan Kettering Institute, MSKCC, 430 East 67th Street, New York, New York 10065, United States., Black WC; Repare Therapeutics, 7171 Frederick-Banting, Building 2, Montréal, Québec H4S 1Z9, Canada., Durocher D; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Zimmermann M; Repare Therapeutics, 7171 Frederick-Banting, Building 2, Montréal, Québec H4S 1Z9, Canada., Sicheri F; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2026 Jan 07; Vol. 17 (2), pp. 433-440. Date of Electronic Publication: 2026 Jan 07 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Bubenik+M%22">Bubenik M</searchLink>; Repare Therapeutics, 7171 Frederick-Banting, Building 2, Montréal, Québec H4S 1Z9, Canada.<br /><searchLink fieldCode="AU" term="%22Mader+P%22">Mader P</searchLink>; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario M5G 1X5, Canada.<br /><searchLink fieldCode="AU" term="%22Orlicky+S%22">Orlicky S</searchLink>; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario M5G 1X5, Canada.<br /><searchLink fieldCode="AU" term="%22Perryman+AL%22">Perryman AL</searchLink>; Repare Therapeutics, 7171 Frederick-Banting, Building 2, Montréal, Québec H4S 1Z9, Canada.<br /><searchLink fieldCode="AU" term="%22Hamel+M%22">Hamel M</searchLink>; Repare Therapeutics, 7171 Frederick-Banting, Building 2, Montréal, Québec H4S 1Z9, Canada.<br /><searchLink fieldCode="AU" term="%22Godbout+C%22">Godbout C</searchLink>; Repare Therapeutics, 7171 Frederick-Banting, Building 2, Montréal, Québec H4S 1Z9, Canada.<br /><searchLink fieldCode="AU" term="%22Falgueyret+JP%22">Falgueyret JP</searchLink>; Repare Therapeutics, 7171 Frederick-Banting, Building 2, Montréal, Québec H4S 1Z9, Canada.<br /><searchLink fieldCode="AU" term="%22Kurinov+I%22">Kurinov I</searchLink>; Department of Chemistry and Chemical Biology, Cornell University, NE-CAT, Argonne, Illinois 60439, United States.<br /><searchLink fieldCode="AU" term="%22Wong+C%22">Wong C</searchLink>; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario M5G 1X5, Canada.<br /><searchLink fieldCode="AU" term="%22Gingras+AC%22">Gingras AC</searchLink>; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario M5G 1X5, Canada.<br /><searchLink fieldCode="AU" term="%22Mamane+Y%22">Mamane Y</searchLink>; Repare Therapeutics, 7171 Frederick-Banting, Building 2, Montréal, Québec H4S 1Z9, Canada.<br /><searchLink fieldCode="AU" term="%22Zinda+M%22">Zinda M</searchLink>; Repare Therapeutics, 101 Main Street, Suite 1650, Cambridge, Massachusetts 02142, United States.<br /><searchLink fieldCode="AU" term="%22Morris+SJ%22">Morris SJ</searchLink>; Repare Therapeutics, 7171 Frederick-Banting, Building 2, Montréal, Québec H4S 1Z9, Canada.<br /><searchLink fieldCode="AU" term="%22Gallant+M%22">Gallant M</searchLink>; Repare Therapeutics, 7171 Frederick-Banting, Building 2, Montréal, Québec H4S 1Z9, Canada.<br /><searchLink fieldCode="AU" term="%22Sfeir+A%22">Sfeir A</searchLink>; Molecular Biology Program, Sloan Kettering Institute, MSKCC, 430 East 67th Street, New York, New York 10065, United States.<br /><searchLink fieldCode="AU" term="%22Black+WC%22">Black WC</searchLink>; Repare Therapeutics, 7171 Frederick-Banting, Building 2, Montréal, Québec H4S 1Z9, Canada.<br /><searchLink fieldCode="AU" term="%22Durocher+D%22">Durocher D</searchLink>; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Zimmermann+M%22">Zimmermann M</searchLink>; Repare Therapeutics, 7171 Frederick-Banting, Building 2, Montréal, Québec H4S 1Z9, Canada.<br /><searchLink fieldCode="AU" term="%22Sicheri+F%22">Sicheri F</searchLink>; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
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  Data: <searchLink fieldCode="JN" term="%22101521073%22">ACS medicinal chemistry letters</searchLink> [ACS Med Chem Lett] 2026 Jan 07; Vol. 17 (2), pp. 433-440. <i>Date of Electronic Publication: </i>2026 Jan 07 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101521073 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1948-5875 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219485875%22">19485875 </searchLink><i>NLM ISO Abbreviation: </i>ACS Med Chem Lett <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1021/acsmedchemlett.5c00643
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        Text: English
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              Text: 2026 Jan 07
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