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Engineering a bifunctional cellobiose 2-epimerase into an isomerase capable of selective lactulose production.

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Bibliographic Details
Title: Engineering a bifunctional cellobiose 2-epimerase into an isomerase capable of selective lactulose production.
Authors: Toplak A; Fresenius Kabi, I&D Center EnzyPep BV, Urmonderbaan 22, 6167 RD Geleen, the Netherlands. Electronic address: Ana.Toplak@fresenius-kabi.com., Wijma HJ; Biotransformation and Biocatalysis, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), Faculty of Science and Engineering, University of Groningen, Nijenborgh 3, 9747 AG Groningen, the Netherlands., Janssen CJ; Fresenius Kabi, I&D Center EnzyPep BV, Urmonderbaan 22, 6167 RD Geleen, the Netherlands., Houben L; Fresenius Kabi, I&D Center EnzyPep BV, Urmonderbaan 22, 6167 RD Geleen, the Netherlands., Altay M; Fresenius Kabi, I&D Center EnzyPep BV, Urmonderbaan 22, 6167 RD Geleen, the Netherlands., Halmschlag BS; Fresenius Kabi, I&D Center EnzyPep BV, Urmonderbaan 22, 6167 RD Geleen, the Netherlands., Janssen DB; Biotransformation and Biocatalysis, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), Faculty of Science and Engineering, University of Groningen, Nijenborgh 3, 9747 AG Groningen, the Netherlands., Cabri W; Department of Chemistry 'G. Ciamician', Alma Mater Studiorum, University of Bologna, Bologna 40126, Italy., Ricci A; Fresenius Kabi iPSUM, Via Roma 108, 20060, Cassina De Pecchi (MI), Italy. Electronic address: Antonio.Ricci@fresenius-kabi.com.
Source: Bioresource technology [Bioresour Technol] 2026 May; Vol. 447, pp. 134241. Date of Electronic Publication: 2026 Feb 16.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Applied Science Country of Publication: England NLM ID: 9889523 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2976 (Electronic) Linking ISSN: 09608524 NLM ISO Abbreviation: Bioresour Technol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-2976
DOI:10.1016/j.biortech.2026.134241