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Progressive Supranuclear Palsy PERK Haplotype B Selectively Translates DLX1 Promoting Tau Toxicity.

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Title: Progressive Supranuclear Palsy PERK Haplotype B Selectively Translates DLX1 Promoting Tau Toxicity.
Authors: Lessard CB; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.; Department of Neuroscience, University of Florida, Gainesville, Florida 32610.; Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, Florida 32610., Rubio Rubio D; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.; Department of Neuroscience, University of Florida, Gainesville, Florida 32610.; Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, Florida 32610., Tolton S; Department of Biochemistry & Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02215., Criado-Marrero M; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.; Department of Neuroscience, University of Florida, Gainesville, Florida 32610.; Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, Florida 32610., Ravi S; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.; Department of Neuroscience, University of Florida, Gainesville, Florida 32610.; Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, Florida 32610., Garza TN; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.; Department of Neuroscience, University of Florida, Gainesville, Florida 32610.; Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, Florida 32610.; Genetics Institute, University of Florida, Gainesville, Florida 32610., Koren J; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.; Department of Neuroscience, University of Florida, Gainesville, Florida 32610.; Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, Florida 32610., Philips J; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.; Department of Pathology, University of Florida, Gainesville, Florida 32610.; Normal Fixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida 32610., Bagchi P; Departments of Biochemistry, Emory School of Medicine, Atlanta, Georgia 30322., McFarland K; Pharmacology and Chemical Biology, Emory School of Medicine, Atlanta, Georgia 30322., Chhangani D; Department of Neurology, University of Florida, Gainesville, Florida 32610., Golde TE; Pharmacology and Chemical Biology, Emory School of Medicine, Atlanta, Georgia 30322., Giasson BI; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.; Department of Neuroscience, University of Florida, Gainesville, Florida 32610.; Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, Florida 32610., Lewis J; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.; Department of Neuroscience, University of Florida, Gainesville, Florida 32610.; Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, Florida 32610.; Department of Physiological Sciences, College of Veterinary Medicine, Gainesville, Florida 32610., Chakrabarty P; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.; Department of Neuroscience, University of Florida, Gainesville, Florida 32610.; Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, Florida 32610., LaVoie MJ; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.; Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, Florida 32610.; Normal Fixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida 32610.; Department of Neurology, University of Florida, Gainesville, Florida 32610., Borchelt DR; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.; Department of Neuroscience, University of Florida, Gainesville, Florida 32610.; Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, Florida 32610., Seyfried NT; Departments of Biochemistry, Emory School of Medicine, Atlanta, Georgia 30322., Prokop S; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.; Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, Florida 32610.; Department of Pathology, University of Florida, Gainesville, Florida 32610.; Normal Fixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida 32610., Rincon-Limas DE; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.; Department of Neuroscience, University of Florida, Gainesville, Florida 32610.; Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, Florida 32610.; Department of Neurology, University of Florida, Gainesville, Florida 32610., Abisambra JF; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610 j.abisambra@ufl.edu.; Department of Neuroscience, University of Florida, Gainesville, Florida 32610.; Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, Florida 32610.; Genetics Institute, University of Florida, Gainesville, Florida 32610.; Brain Injury Rehabilitation and Neuroresilience (BRAIN) Center, University of Florida, Gainesville, Florida 32610.; Brain Rehabilitation Research Center, Malcom Randall VA Medical Center, North Florida/South Georgia Veterans Health System, Gainesville, Florida 32608.
Source: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2026 Apr 01; Vol. 46 (13). Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE
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  Data: Progressive Supranuclear Palsy PERK Haplotype B Selectively Translates DLX1 Promoting Tau Toxicity.
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  Data: <searchLink fieldCode="AU" term="%22Lessard+CB%22">Lessard CB</searchLink>; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.; Department of Neuroscience, University of Florida, Gainesville, Florida 32610.; Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, Florida 32610.<br /><searchLink fieldCode="AU" term="%22Rubio+Rubio+D%22">Rubio Rubio D</searchLink>; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.; Department of Neuroscience, University of Florida, Gainesville, Florida 32610.; Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, Florida 32610.<br /><searchLink fieldCode="AU" term="%22Tolton+S%22">Tolton S</searchLink>; Department of Biochemistry & Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02215.<br /><searchLink fieldCode="AU" term="%22Criado-Marrero+M%22">Criado-Marrero M</searchLink>; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.; Department of Neuroscience, University of Florida, Gainesville, Florida 32610.; Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, Florida 32610.<br /><searchLink fieldCode="AU" term="%22Ravi+S%22">Ravi S</searchLink>; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.; Department of Neuroscience, University of Florida, Gainesville, Florida 32610.; Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, Florida 32610.<br /><searchLink fieldCode="AU" term="%22Garza+TN%22">Garza TN</searchLink>; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.; Department of Neuroscience, University of Florida, Gainesville, Florida 32610.; Evelyn F. and William L. 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McKnight Brain Institute, University of Florida, Gainesville, Florida 32610.<br /><searchLink fieldCode="AU" term="%22Lewis+J%22">Lewis J</searchLink>; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.; Department of Neuroscience, University of Florida, Gainesville, Florida 32610.; Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, Florida 32610.; Department of Physiological Sciences, College of Veterinary Medicine, Gainesville, Florida 32610.<br /><searchLink fieldCode="AU" term="%22Chakrabarty+P%22">Chakrabarty P</searchLink>; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.; Department of Neuroscience, University of Florida, Gainesville, Florida 32610.; Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, Florida 32610.<br /><searchLink fieldCode="AU" term="%22LaVoie+MJ%22">LaVoie MJ</searchLink>; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.; Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, Florida 32610.; Normal Fixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida 32610.; Department of Neurology, University of Florida, Gainesville, Florida 32610.<br /><searchLink fieldCode="AU" term="%22Borchelt+DR%22">Borchelt DR</searchLink>; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.; Department of Neuroscience, University of Florida, Gainesville, Florida 32610.; Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, Florida 32610.<br /><searchLink fieldCode="AU" term="%22Seyfried+NT%22">Seyfried NT</searchLink>; Departments of Biochemistry, Emory School of Medicine, Atlanta, Georgia 30322.<br /><searchLink fieldCode="AU" term="%22Prokop+S%22">Prokop S</searchLink>; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.; Evelyn F. and William L. 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