In vivo base editing of Chd3 rescues behavioural abnormalities in mice.

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Title: In vivo base editing of Chd3 rescues behavioural abnormalities in mice.
Authors: Yang K; Department of Developmental and Behavioral Pediatric and Child Primary Care, Brain and Behavioral Research Unit of Shanghai Institute for Pediatric Research and MOE-Shanghai Key Laboratory for Children's Environmental Health of Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. kanyang@shsmu.edu.cn.; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. kanyang@shsmu.edu.cn.; College of Materials and Chemical Engineering, Hunan Institute of Engineering, Xiangtan, China. kanyang@shsmu.edu.cn., Li WK; Institute of Pediatrics, National Children's Medical Center, Children's Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China., Geng YX; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; College of Basic Medical Science, Shanghai Jiao Tong University School of medicine, Shanghai, China., Zhang SQ; Department of Pediatrics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China., Wu SH; School of Medicine, Yunnan University, Kunming, China., Cheng YB; State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.; School of Life Science and Technology, Shanghai Tech University, Shanghai, China., Wang JW; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Xu ZK; College of Materials and Chemical Engineering, Hunan Institute of Engineering, Xiangtan, China., Wang WX; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; College of Biological Science and Medical Engineering, Donghua University, Shanghai, China., Zhang TY; College of Materials and Chemical Engineering, Hunan Institute of Engineering, Xiangtan, China., Wang PY; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; College of Basic Medical Science, Shanghai Jiao Tong University School of medicine, Shanghai, China., Yuan YT; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Fan J; College of Materials and Chemical Engineering, Hunan Institute of Engineering, Xiangtan, China., Wu J; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Xu RC; College of Basic Medical Science, Shanghai Jiao Tong University School of medicine, Shanghai, China., Zhang YF; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Tao GJ; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Li ZH; Qianweichang College, Shanghai University, Shanghai, China., Lin CX; College of Basic Medical Science, Shanghai Jiao Tong University School of medicine, Shanghai, China., Li TS; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Zhang XY; Institute of Pediatrics, National Children's Medical Center, Children's Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China., Li J; Institute of Pediatrics, National Children's Medical Center, Children's Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China., Zhang R; College of Materials and Chemical Engineering, Hunan Institute of Engineering, Xiangtan, China., Yang WX; School of Medicine, Yunnan University, Kunming, China., Wen JS; School of Medicine, Yunnan University, Kunming, China., Yang ZY; PriMed Non-human Primate Research Center, Sichuan PriMed Shines Bio-tech, Ya'an, China., Gong L; PriMed Non-human Primate Research Center, Sichuan PriMed Shines Bio-tech, Ya'an, China., Zeng W; PriMed Non-human Primate Research Center, Sichuan PriMed Shines Bio-tech, Ya'an, China., Du AL; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Li JS; State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.; School of Life Science and Technology, Shanghai Tech University, Shanghai, China., Li F; Department of Developmental and Behavioral Pediatric and Child Primary Care, Brain and Behavioral Research Unit of Shanghai Institute for Pediatric Research and MOE-Shanghai Key Laboratory for Children's Environmental Health of Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. feili@shsmu.edu.cn., Cheng TL; Institute of Pediatrics, National Children's Medical Center, Children's Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China. chengtianlin@fudan.edu.cn., Qiu Z; Department of Developmental and Behavioral Pediatric and Child Primary Care, Brain and Behavioral Research Unit of Shanghai Institute for Pediatric Research and MOE-Shanghai Key Laboratory for Children's Environmental Health of Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. qiuzilong@shsmu.edu.cn.; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. qiuzilong@shsmu.edu.cn.
Source: Nature [Nature] 2026 Mar; Vol. 651 (8106), pp. 785-795. Date of Electronic Publication: 2026 Feb 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4687
DOI:10.1038/s41586-026-10113-6