View in EDS

In vivo base editing of Chd3 rescues behavioural abnormalities in mice.

Saved in:
Bibliographic Details
Title: In vivo base editing of Chd3 rescues behavioural abnormalities in mice.
Authors: Yang K; Department of Developmental and Behavioral Pediatric and Child Primary Care, Brain and Behavioral Research Unit of Shanghai Institute for Pediatric Research and MOE-Shanghai Key Laboratory for Children's Environmental Health of Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. kanyang@shsmu.edu.cn.; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. kanyang@shsmu.edu.cn.; College of Materials and Chemical Engineering, Hunan Institute of Engineering, Xiangtan, China. kanyang@shsmu.edu.cn., Li WK; Institute of Pediatrics, National Children's Medical Center, Children's Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China., Geng YX; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; College of Basic Medical Science, Shanghai Jiao Tong University School of medicine, Shanghai, China., Zhang SQ; Department of Pediatrics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China., Wu SH; School of Medicine, Yunnan University, Kunming, China., Cheng YB; State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.; School of Life Science and Technology, Shanghai Tech University, Shanghai, China., Wang JW; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Xu ZK; College of Materials and Chemical Engineering, Hunan Institute of Engineering, Xiangtan, China., Wang WX; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; College of Biological Science and Medical Engineering, Donghua University, Shanghai, China., Zhang TY; College of Materials and Chemical Engineering, Hunan Institute of Engineering, Xiangtan, China., Wang PY; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; College of Basic Medical Science, Shanghai Jiao Tong University School of medicine, Shanghai, China., Yuan YT; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Fan J; College of Materials and Chemical Engineering, Hunan Institute of Engineering, Xiangtan, China., Wu J; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Xu RC; College of Basic Medical Science, Shanghai Jiao Tong University School of medicine, Shanghai, China., Zhang YF; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Tao GJ; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Li ZH; Qianweichang College, Shanghai University, Shanghai, China., Lin CX; College of Basic Medical Science, Shanghai Jiao Tong University School of medicine, Shanghai, China., Li TS; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Zhang XY; Institute of Pediatrics, National Children's Medical Center, Children's Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China., Li J; Institute of Pediatrics, National Children's Medical Center, Children's Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China., Zhang R; College of Materials and Chemical Engineering, Hunan Institute of Engineering, Xiangtan, China., Yang WX; School of Medicine, Yunnan University, Kunming, China., Wen JS; School of Medicine, Yunnan University, Kunming, China., Yang ZY; PriMed Non-human Primate Research Center, Sichuan PriMed Shines Bio-tech, Ya'an, China., Gong L; PriMed Non-human Primate Research Center, Sichuan PriMed Shines Bio-tech, Ya'an, China., Zeng W; PriMed Non-human Primate Research Center, Sichuan PriMed Shines Bio-tech, Ya'an, China., Du AL; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Li JS; State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.; School of Life Science and Technology, Shanghai Tech University, Shanghai, China., Li F; Department of Developmental and Behavioral Pediatric and Child Primary Care, Brain and Behavioral Research Unit of Shanghai Institute for Pediatric Research and MOE-Shanghai Key Laboratory for Children's Environmental Health of Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. feili@shsmu.edu.cn., Cheng TL; Institute of Pediatrics, National Children's Medical Center, Children's Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China. chengtianlin@fudan.edu.cn., Qiu Z; Department of Developmental and Behavioral Pediatric and Child Primary Care, Brain and Behavioral Research Unit of Shanghai Institute for Pediatric Research and MOE-Shanghai Key Laboratory for Children's Environmental Health of Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. qiuzilong@shsmu.edu.cn.; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. qiuzilong@shsmu.edu.cn.
Source: Nature [Nature] 2026 Mar; Vol. 651 (8106), pp. 785-795. Date of Electronic Publication: 2026 Feb 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41708849
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: In vivo base editing of Chd3 rescues behavioural abnormalities in mice.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Yang+K%22">Yang K</searchLink>; Department of Developmental and Behavioral Pediatric and Child Primary Care, Brain and Behavioral Research Unit of Shanghai Institute for Pediatric Research and MOE-Shanghai Key Laboratory for Children's Environmental Health of Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. kanyang@shsmu.edu.cn.; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. kanyang@shsmu.edu.cn.; College of Materials and Chemical Engineering, Hunan Institute of Engineering, Xiangtan, China. kanyang@shsmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Li+WK%22">Li WK</searchLink>; Institute of Pediatrics, National Children's Medical Center, Children's Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Geng+YX%22">Geng YX</searchLink>; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; College of Basic Medical Science, Shanghai Jiao Tong University School of medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+SQ%22">Zhang SQ</searchLink>; Department of Pediatrics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.<br /><searchLink fieldCode="AU" term="%22Wu+SH%22">Wu SH</searchLink>; School of Medicine, Yunnan University, Kunming, China.<br /><searchLink fieldCode="AU" term="%22Cheng+YB%22">Cheng YB</searchLink>; State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.; School of Life Science and Technology, Shanghai Tech University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+JW%22">Wang JW</searchLink>; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Xu+ZK%22">Xu ZK</searchLink>; College of Materials and Chemical Engineering, Hunan Institute of Engineering, Xiangtan, China.<br /><searchLink fieldCode="AU" term="%22Wang+WX%22">Wang WX</searchLink>; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; College of Biological Science and Medical Engineering, Donghua University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+TY%22">Zhang TY</searchLink>; College of Materials and Chemical Engineering, Hunan Institute of Engineering, Xiangtan, China.<br /><searchLink fieldCode="AU" term="%22Wang+PY%22">Wang PY</searchLink>; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; College of Basic Medical Science, Shanghai Jiao Tong University School of medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Yuan+YT%22">Yuan YT</searchLink>; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Fan+J%22">Fan J</searchLink>; College of Materials and Chemical Engineering, Hunan Institute of Engineering, Xiangtan, China.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Xu+RC%22">Xu RC</searchLink>; College of Basic Medical Science, Shanghai Jiao Tong University School of medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+YF%22">Zhang YF</searchLink>; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Tao+GJ%22">Tao GJ</searchLink>; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Li+ZH%22">Li ZH</searchLink>; Qianweichang College, Shanghai University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Lin+CX%22">Lin CX</searchLink>; College of Basic Medical Science, Shanghai Jiao Tong University School of medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Li+TS%22">Li TS</searchLink>; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+XY%22">Zhang XY</searchLink>; Institute of Pediatrics, National Children's Medical Center, Children's Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Institute of Pediatrics, National Children's Medical Center, Children's Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; College of Materials and Chemical Engineering, Hunan Institute of Engineering, Xiangtan, China.<br /><searchLink fieldCode="AU" term="%22Yang+WX%22">Yang WX</searchLink>; School of Medicine, Yunnan University, Kunming, China.<br /><searchLink fieldCode="AU" term="%22Wen+JS%22">Wen JS</searchLink>; School of Medicine, Yunnan University, Kunming, China.<br /><searchLink fieldCode="AU" term="%22Yang+ZY%22">Yang ZY</searchLink>; PriMed Non-human Primate Research Center, Sichuan PriMed Shines Bio-tech, Ya'an, China.<br /><searchLink fieldCode="AU" term="%22Gong+L%22">Gong L</searchLink>; PriMed Non-human Primate Research Center, Sichuan PriMed Shines Bio-tech, Ya'an, China.<br /><searchLink fieldCode="AU" term="%22Zeng+W%22">Zeng W</searchLink>; PriMed Non-human Primate Research Center, Sichuan PriMed Shines Bio-tech, Ya'an, China.<br /><searchLink fieldCode="AU" term="%22Du+AL%22">Du AL</searchLink>; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Li+JS%22">Li JS</searchLink>; State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.; School of Life Science and Technology, Shanghai Tech University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Li+F%22">Li F</searchLink>; Department of Developmental and Behavioral Pediatric and Child Primary Care, Brain and Behavioral Research Unit of Shanghai Institute for Pediatric Research and MOE-Shanghai Key Laboratory for Children's Environmental Health of Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. feili@shsmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Cheng+TL%22">Cheng TL</searchLink>; Institute of Pediatrics, National Children's Medical Center, Children's Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China. chengtianlin@fudan.edu.cn.<br /><searchLink fieldCode="AU" term="%22Qiu+Z%22">Qiu Z</searchLink>; Department of Developmental and Behavioral Pediatric and Child Primary Care, Brain and Behavioral Research Unit of Shanghai Institute for Pediatric Research and MOE-Shanghai Key Laboratory for Children's Environmental Health of Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. qiuzilong@shsmu.edu.cn.; Department of Neurology, Songjiang Hospital, Songjiang Research Institute, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. qiuzilong@shsmu.edu.cn.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2026 Mar; Vol. 651 (8106), pp. 785-795. <i>Date of Electronic Publication: </i>2026 Feb 18.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0410462 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-4687 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200280836%22">00280836 </searchLink><i>NLM ISO Abbreviation: </i>Nature <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41708849
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41586-026-10113-6
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 785
    Titles:
      – TitleFull: In vivo base editing of Chd3 rescues behavioural abnormalities in mice.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Yang K
      – PersonEntity:
          Name:
            NameFull: Li WK
      – PersonEntity:
          Name:
            NameFull: Geng YX
      – PersonEntity:
          Name:
            NameFull: Zhang SQ
      – PersonEntity:
          Name:
            NameFull: Wu SH
      – PersonEntity:
          Name:
            NameFull: Cheng YB
      – PersonEntity:
          Name:
            NameFull: Wang JW
      – PersonEntity:
          Name:
            NameFull: Xu ZK
      – PersonEntity:
          Name:
            NameFull: Wang WX
      – PersonEntity:
          Name:
            NameFull: Zhang TY
      – PersonEntity:
          Name:
            NameFull: Wang PY
      – PersonEntity:
          Name:
            NameFull: Yuan YT
      – PersonEntity:
          Name:
            NameFull: Fan J
      – PersonEntity:
          Name:
            NameFull: Wu J
      – PersonEntity:
          Name:
            NameFull: Xu RC
      – PersonEntity:
          Name:
            NameFull: Zhang YF
      – PersonEntity:
          Name:
            NameFull: Tao GJ
      – PersonEntity:
          Name:
            NameFull: Li ZH
      – PersonEntity:
          Name:
            NameFull: Lin CX
      – PersonEntity:
          Name:
            NameFull: Li TS
      – PersonEntity:
          Name:
            NameFull: Zhang XY
      – PersonEntity:
          Name:
            NameFull: Li J
      – PersonEntity:
          Name:
            NameFull: Zhang R
      – PersonEntity:
          Name:
            NameFull: Yang WX
      – PersonEntity:
          Name:
            NameFull: Wen JS
      – PersonEntity:
          Name:
            NameFull: Yang ZY
      – PersonEntity:
          Name:
            NameFull: Gong L
      – PersonEntity:
          Name:
            NameFull: Zeng W
      – PersonEntity:
          Name:
            NameFull: Du AL
      – PersonEntity:
          Name:
            NameFull: Li JS
      – PersonEntity:
          Name:
            NameFull: Li F
      – PersonEntity:
          Name:
            NameFull: Cheng TL
      – PersonEntity:
          Name:
            NameFull: Qiu Z
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 03
              Text: 2026 Mar
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1476-4687
          Numbering:
            – Type: volume
              Value: 651
            – Type: issue
              Value: 8106
          Titles:
            – TitleFull: Nature
              Type: main
ResultId 1