KRAS-dependent glycolytic reprogramming of endothelial cells in sporadic arteriovenous malformations.
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| Title: | KRAS-dependent glycolytic reprogramming of endothelial cells in sporadic arteriovenous malformations. |
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| Authors: | Wu R; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada., Khosraviani N; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada., Mansur A; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Boudreau E; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada., Largoza GE; Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, USA.; Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA., Park S; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada., Gustafson D; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.; Department of Public Health Sciences, Queen's University, Kingston, ON, Canada., Raju S; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Division of Vascular Surgery, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada., Ching C; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Klip A; Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Wälchli T; Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.; Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, University College London Hospitals, London, UK.; Division of Neurosurgery, University Hospital Zurich, Zurich, Switzerland., Howe KL; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Division of Vascular Surgery, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada.; Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada., Radovanovic I; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada., Wythe JD; Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, USA.; Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA., Fish JE; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. jason.fish@utoronto.ca.; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada. jason.fish@utoronto.ca.; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. jason.fish@utoronto.ca.; Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada. jason.fish@utoronto.ca. |
| Source: | EMBO molecular medicine [EMBO Mol Med] 2026 Mar; Vol. 18 (3), pp. 1091-1126. Date of Electronic Publication: 2026 Feb 18. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1757-4684 |
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| DOI: | 10.1038/s44321-026-00383-y |
