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KRAS-dependent glycolytic reprogramming of endothelial cells in sporadic arteriovenous malformations.

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Title: KRAS-dependent glycolytic reprogramming of endothelial cells in sporadic arteriovenous malformations.
Authors: Wu R; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada., Khosraviani N; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada., Mansur A; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Boudreau E; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada., Largoza GE; Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, USA.; Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA., Park S; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada., Gustafson D; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.; Department of Public Health Sciences, Queen's University, Kingston, ON, Canada., Raju S; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Division of Vascular Surgery, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada., Ching C; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Klip A; Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Wälchli T; Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.; Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, University College London Hospitals, London, UK.; Division of Neurosurgery, University Hospital Zurich, Zurich, Switzerland., Howe KL; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Division of Vascular Surgery, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada.; Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada., Radovanovic I; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada., Wythe JD; Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, USA.; Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA., Fish JE; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. jason.fish@utoronto.ca.; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada. jason.fish@utoronto.ca.; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. jason.fish@utoronto.ca.; Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada. jason.fish@utoronto.ca.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 Mar; Vol. 18 (3), pp. 1091-1126. Date of Electronic Publication: 2026 Feb 18.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
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  Data: KRAS-dependent glycolytic reprogramming of endothelial cells in sporadic arteriovenous malformations.
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  Data: <searchLink fieldCode="AU" term="%22Wu+R%22">Wu R</searchLink>; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Khosraviani+N%22">Khosraviani N</searchLink>; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Mansur+A%22">Mansur A</searchLink>; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Boudreau+E%22">Boudreau E</searchLink>; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Largoza+GE%22">Largoza GE</searchLink>; Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, USA.; Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Park+S%22">Park S</searchLink>; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Gustafson+D%22">Gustafson D</searchLink>; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.; Department of Public Health Sciences, Queen's University, Kingston, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Raju+S%22">Raju S</searchLink>; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Division of Vascular Surgery, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Ching+C%22">Ching C</searchLink>; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Klip+A%22">Klip A</searchLink>; Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Wälchli+T%22">Wälchli T</searchLink>; Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.; Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, University College London Hospitals, London, UK.; Division of Neurosurgery, University Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Howe+KL%22">Howe KL</searchLink>; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Division of Vascular Surgery, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada.; Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Radovanovic+I%22">Radovanovic I</searchLink>; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Wythe+JD%22">Wythe JD</searchLink>; Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, USA.; Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Fish+JE%22">Fish JE</searchLink>; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. jason.fish@utoronto.ca.; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada. jason.fish@utoronto.ca.; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. jason.fish@utoronto.ca.; Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada. jason.fish@utoronto.ca.
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