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Supramolecular delivery of senolytics enables targeted anti-senescence therapy and accelerated fracture healing.

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Title: Supramolecular delivery of senolytics enables targeted anti-senescence therapy and accelerated fracture healing.
Authors: Fan Y; School of Medicine, Nankai University, Tianjin, China.; Department of Spinal Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, 300121, China., Wang ZH; College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), Collaborative Innovation Center of Chemical Science and Engineering, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin, 300071, China., Zhang X; School of Medicine, Nankai University, Tianjin, China., Dong Y; School of Medicine, Nankai University, Tianjin, China.; Department of Spinal Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, 300121, China., Liu X; Tianjin Medical University, Tianjin, China., Luo G; Tianjin Medical University, Tianjin, China., Yang H; Tianjin Medical University, Tianjin, China., Li H; Department of Spinal Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, 300121, China., Wang Z; School of Medicine, Nankai University, Tianjin, China., Tang Q; Department of Respiratory, Tianjin Union Medical Center, Tianjin, 300121, China., Jin X; School of Medicine, Nankai University, Tianjin, China. xin.jin@nankai.edu.cn.; Academy for Advanced Interdisciplinary Studies, Nankai University, Tianjin, 300071, China. xin.jin@nankai.edu.cn., Guo DS; College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), Collaborative Innovation Center of Chemical Science and Engineering, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin, 300071, China. dshguo@nankai.edu.cn., Sun T; School of Medicine, Nankai University, Tianjin, China. billsuntw@163.com.; Department of Spinal Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, 300121, China. billsuntw@163.com.; Tianjin Institute of Spinal Surgery, Tianjin, 300121, China. billsuntw@163.com.; Tianjin Medical University, Tianjin, China. billsuntw@163.com.
Source: Journal of nanobiotechnology [J Nanobiotechnology] 2026 Feb 18; Vol. 24 (1). Date of Electronic Publication: 2026 Feb 18.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Supramolecular delivery of senolytics enables targeted anti-senescence therapy and accelerated fracture healing.
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  Data: <searchLink fieldCode="AU" term="%22Fan+Y%22">Fan Y</searchLink>; School of Medicine, Nankai University, Tianjin, China.; Department of Spinal Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, 300121, China.<br /><searchLink fieldCode="AU" term="%22Wang+ZH%22">Wang ZH</searchLink>; College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), Collaborative Innovation Center of Chemical Science and Engineering, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin, 300071, China.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; School of Medicine, Nankai University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Dong+Y%22">Dong Y</searchLink>; School of Medicine, Nankai University, Tianjin, China.; Department of Spinal Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, 300121, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Tianjin Medical University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Luo+G%22">Luo G</searchLink>; Tianjin Medical University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Yang+H%22">Yang H</searchLink>; Tianjin Medical University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Department of Spinal Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, 300121, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; School of Medicine, Nankai University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Tang+Q%22">Tang Q</searchLink>; Department of Respiratory, Tianjin Union Medical Center, Tianjin, 300121, China.<br /><searchLink fieldCode="AU" term="%22Jin+X%22">Jin X</searchLink>; School of Medicine, Nankai University, Tianjin, China. xin.jin@nankai.edu.cn.; Academy for Advanced Interdisciplinary Studies, Nankai University, Tianjin, 300071, China. xin.jin@nankai.edu.cn.<br /><searchLink fieldCode="AU" term="%22Guo+DS%22">Guo DS</searchLink>; College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), Collaborative Innovation Center of Chemical Science and Engineering, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin, 300071, China. dshguo@nankai.edu.cn.<br /><searchLink fieldCode="AU" term="%22Sun+T%22">Sun T</searchLink>; School of Medicine, Nankai University, Tianjin, China. billsuntw@163.com.; Department of Spinal Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, 300121, China. billsuntw@163.com.; Tianjin Institute of Spinal Surgery, Tianjin, 300121, China. billsuntw@163.com.; Tianjin Medical University, Tianjin, China. billsuntw@163.com.
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  Data: <searchLink fieldCode="JN" term="%22101152208%22">Journal of nanobiotechnology</searchLink> [J Nanobiotechnology] 2026 Feb 18; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 Feb 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101152208 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1477-3155 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214773155%22">14773155 </searchLink><i>NLM ISO Abbreviation: </i>J Nanobiotechnology <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12951-026-04138-2
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              Text: 2026 Feb 18
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              Y: 2026
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