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Human neuromuscular organoids mimic cancer-induced muscle cachexia.

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Title: Human neuromuscular organoids mimic cancer-induced muscle cachexia.
Authors: Chiolerio P; Department of Molecular Medicine, University of Padova, Via G. Colombo 3, 35131 Padova, Italy; Neuromuscular Engineering Lab, Istituto di Ricerca Pediatrica, Città Della Speranza, Corso Stati Uniti 4/F, 35127 Padova, Italy., Auletta B; Department of Molecular Medicine, University of Padova, Via G. Colombo 3, 35131 Padova, Italy; Neuromuscular Engineering Lab, Istituto di Ricerca Pediatrica, Città Della Speranza, Corso Stati Uniti 4/F, 35127 Padova, Italy; Department of Industrial Engineering, University of Padova, Via Gradenigo 6/a, 35131 Padova, Italy., Pezzini C; Department of Biomedical Sciences, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy; Veneto Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy., Sartore L; Department of Molecular Medicine, University of Padova, Via G. Colombo 3, 35131 Padova, Italy; Neuromuscular Engineering Lab, Istituto di Ricerca Pediatrica, Città Della Speranza, Corso Stati Uniti 4/F, 35127 Padova, Italy., Gregolon G; Department of Molecular Medicine, University of Padova, Via G. Colombo 3, 35131 Padova, Italy; Neuromuscular Engineering Lab, Istituto di Ricerca Pediatrica, Città Della Speranza, Corso Stati Uniti 4/F, 35127 Padova, Italy., Gagliano O; Department of Industrial Engineering, University of Padova, Via Gradenigo 6/a, 35131 Padova, Italy; Veneto Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy., Laterza C; Department of Biomedical Sciences, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy; Veneto Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy., Balmaceda Valdez VR; Department of Biomedical Sciences, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy; Veneto Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy., Cacchiarelli D; Telethon Institute of Genetics and Medicine (TIGEM), Armenise/Harvard Laboratory of Integrative Genomics, Via Campi Flegrei 34, 80078 Pozzuoli, Italy; Department of Translational Medicine, University of Naples 'Federico II', Naples, Italy; Genomics and Experimental Medicine Program, Scuola Superiore Meridionale (SSM, School of Advanced Studies), Naples, Italy., Luni C; Department of Civil, Chemical, Environmental and Materials Engineering (DICAM), University of Bologna, Via Terracini 28, 40131 Bologna, Italy., Viscomi C; Department of Biomedical Sciences, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy; Veneto Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy., Planque M; Spatial Metabolomics Expertise Center, VIB Center for Cancer Biology, VIB, Leuven, Belgium., Fendt SM; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium., Sandri M; Department of Biomedical Sciences, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy; Veneto Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy., Sartori R; Department of Biomedical Sciences, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy; Veneto Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy. Electronic address: roberta.sartori@unipd.it., Urciuolo A; Department of Molecular Medicine, University of Padova, Via G. Colombo 3, 35131 Padova, Italy; Neuromuscular Engineering Lab, Istituto di Ricerca Pediatrica, Città Della Speranza, Corso Stati Uniti 4/F, 35127 Padova, Italy. Electronic address: anna.urciuolo@unipd.it.
Source: Cell reports methods [Cell Rep Methods] 2026 Feb 23; Vol. 6 (2), pp. 101331. Date of Electronic Publication: 2026 Feb 17.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 9918227360606676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2667-2375 (Electronic) Linking ISSN: 26672375 NLM ISO Abbreviation: Cell Rep Methods Subsets: MEDLINE
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  Data: Human neuromuscular organoids mimic cancer-induced muscle cachexia.
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  Data: <searchLink fieldCode="AU" term="%22Chiolerio+P%22">Chiolerio P</searchLink>; Department of Molecular Medicine, University of Padova, Via G. Colombo 3, 35131 Padova, Italy; Neuromuscular Engineering Lab, Istituto di Ricerca Pediatrica, Città Della Speranza, Corso Stati Uniti 4/F, 35127 Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Auletta+B%22">Auletta B</searchLink>; Department of Molecular Medicine, University of Padova, Via G. Colombo 3, 35131 Padova, Italy; Neuromuscular Engineering Lab, Istituto di Ricerca Pediatrica, Città Della Speranza, Corso Stati Uniti 4/F, 35127 Padova, Italy; Department of Industrial Engineering, University of Padova, Via Gradenigo 6/a, 35131 Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Pezzini+C%22">Pezzini C</searchLink>; Department of Biomedical Sciences, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy; Veneto Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Sartore+L%22">Sartore L</searchLink>; Department of Molecular Medicine, University of Padova, Via G. Colombo 3, 35131 Padova, Italy; Neuromuscular Engineering Lab, Istituto di Ricerca Pediatrica, Città Della Speranza, Corso Stati Uniti 4/F, 35127 Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Gregolon+G%22">Gregolon G</searchLink>; Department of Molecular Medicine, University of Padova, Via G. Colombo 3, 35131 Padova, Italy; Neuromuscular Engineering Lab, Istituto di Ricerca Pediatrica, Città Della Speranza, Corso Stati Uniti 4/F, 35127 Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Gagliano+O%22">Gagliano O</searchLink>; Department of Industrial Engineering, University of Padova, Via Gradenigo 6/a, 35131 Padova, Italy; Veneto Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Laterza+C%22">Laterza C</searchLink>; Department of Biomedical Sciences, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy; Veneto Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Balmaceda+Valdez+VR%22">Balmaceda Valdez VR</searchLink>; Department of Biomedical Sciences, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy; Veneto Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Cacchiarelli+D%22">Cacchiarelli D</searchLink>; Telethon Institute of Genetics and Medicine (TIGEM), Armenise/Harvard Laboratory of Integrative Genomics, Via Campi Flegrei 34, 80078 Pozzuoli, Italy; Department of Translational Medicine, University of Naples 'Federico II', Naples, Italy; Genomics and Experimental Medicine Program, Scuola Superiore Meridionale (SSM, School of Advanced Studies), Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Luni+C%22">Luni C</searchLink>; Department of Civil, Chemical, Environmental and Materials Engineering (DICAM), University of Bologna, Via Terracini 28, 40131 Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Viscomi+C%22">Viscomi C</searchLink>; Department of Biomedical Sciences, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy; Veneto Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Planque+M%22">Planque M</searchLink>; Spatial Metabolomics Expertise Center, VIB Center for Cancer Biology, VIB, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Fendt+SM%22">Fendt SM</searchLink>; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Sandri+M%22">Sandri M</searchLink>; Department of Biomedical Sciences, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy; Veneto Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Sartori+R%22">Sartori R</searchLink>; Department of Biomedical Sciences, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy; Veneto Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy. Electronic address: roberta.sartori@unipd.it.<br /><searchLink fieldCode="AU" term="%22Urciuolo+A%22">Urciuolo A</searchLink>; Department of Molecular Medicine, University of Padova, Via G. Colombo 3, 35131 Padova, Italy; Neuromuscular Engineering Lab, Istituto di Ricerca Pediatrica, Città Della Speranza, Corso Stati Uniti 4/F, 35127 Padova, Italy. Electronic address: anna.urciuolo@unipd.it.
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