Rapid directed evolution guided by protein language models and epistatic interactions.
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| Title: | Rapid directed evolution guided by protein language models and epistatic interactions. |
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| Authors: | Tran VQ; Arc Institute, Palo Alto, CA, USA.; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA., Nemeth M; Arc Institute, Palo Alto, CA, USA., Bartie LJ; Arc Institute, Palo Alto, CA, USA., Chandrasekaran SS; Arc Institute, Palo Alto, CA, USA.; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.; San Francisco Graduate Program in Bioengineering, University of California, Berkeley, Berkeley, CA, USA., Fanton A; Arc Institute, Palo Alto, CA, USA.; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.; San Francisco Graduate Program in Bioengineering, University of California, Berkeley, Berkeley, CA, USA., Moon HC; Arc Institute, Palo Alto, CA, USA., Hie BL; Arc Institute, Palo Alto, CA, USA.; Department of Chemical Engineering, Stanford University, Stanford, CA, USA.; Stanford Data Science, Stanford University, Stanford, CA, USA., Konermann S; Arc Institute, Palo Alto, CA, USA.; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA., Hsu PD; Arc Institute, Palo Alto, CA, USA.; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.; Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA. |
| Source: | Science (New York, N.Y.) [Science] 2026 May 07; Vol. 392 (6798), pp. eaea1820. Date of Electronic Publication: 2026 May 07. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.aea1820 |
