mTOR-driven autophagy suppression defines metabolic vulnerability in CDK4/6 inhibitor-resistant HR+/HER2- breast cancer.

Saved in:
Bibliographic Details
Title: mTOR-driven autophagy suppression defines metabolic vulnerability in CDK4/6 inhibitor-resistant HR+/HER2- breast cancer.
Authors: von Wichert L; Institute of Molecular Oncology, Universities of Gießen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Philipps-University, Marburg, Germany.; Department of Gynecology, Gynecological Endocrinology and Oncology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany., Stroh A; Institute of Molecular Oncology, Universities of Gießen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Philipps-University, Marburg, Germany.; Department of Gynecology, Gynecological Endocrinology and Oncology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany., Witt M; Institute of Molecular Oncology, Universities of Gießen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Philipps-University, Marburg, Germany.; Department of Gynecology, Gynecological Endocrinology and Oncology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany., Wanzel M; Institute of Molecular Oncology, Universities of Gießen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Philipps-University, Marburg, Germany., Mernberger M; Institute of Molecular Oncology, Universities of Gießen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Philipps-University, Marburg, Germany., Griewing S; Department of Gynecology, Gynecological Endocrinology and Oncology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany., Wündisch T; Comprehensive Cancer Center Marburg, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany., Pfitzner BM; Institute of Pathology, DRK Clinics Westend, Berlin, Germany., Teply-Szymanski J; Institute of Pathology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany., Litmeyer AS; Institute of Pathology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany., Denkert C; Institute of Pathology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany., Wagner U; Department of Gynecology, Gynecological Endocrinology and Oncology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany., Stiewe T; Institute of Molecular Oncology, Universities of Gießen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Philipps-University, Marburg, Germany.; Genomics Core Facility, Philipps-University, Marburg, Germany.; Institute of Lung Health, Justus Liebig University, Gießen, Germany., Gremke N; Institute of Molecular Oncology, Universities of Gießen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Philipps-University, Marburg, Germany. Gremken@staff.uni-marburg.de.; Department of Gynecology, Gynecological Endocrinology and Oncology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany. Gremken@staff.uni-marburg.de.
Source: Cell death & disease [Cell Death Dis] 2026 Feb 19; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-4889
DOI:10.1038/s41419-026-08496-5