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Trabectedin plus CD13-targeted tissue factor tTF-NGR against advanced relapsed or refractory soft tissue sarcoma: translational data, clinical safety and efficacy.

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Title: Trabectedin plus CD13-targeted tissue factor tTF-NGR against advanced relapsed or refractory soft tissue sarcoma: translational data, clinical safety and efficacy.
Authors: Hessling K; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital of Muenster, Albert‑Schweitzer‑Campus 1, 48149, Muenster, Germany., Brand C; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital of Muenster, Albert‑Schweitzer‑Campus 1, 48149, Muenster, Germany., Schwöppe C; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital of Muenster, Albert‑Schweitzer‑Campus 1, 48149, Muenster, Germany., Gerwing M; Department of Radiology, University Hospital Muenster, Muenster, Germany., Pavelka S; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital of Muenster, Albert‑Schweitzer‑Campus 1, 48149, Muenster, Germany., Berdel AF; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital of Muenster, Albert‑Schweitzer‑Campus 1, 48149, Muenster, Germany., Hintelmann H; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital of Muenster, Albert‑Schweitzer‑Campus 1, 48149, Muenster, Germany., Hamacher R; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany., Müller-Tidow C; Center for Internal Medicine 5, University Hospital Heidelberg, Heidelberg, Germany., Egerer G; Center for Internal Medicine 5, University Hospital Heidelberg, Heidelberg, Germany., Hartmann W; Gerhard-Domagk-Institute for Pathology, University Hospital Muenster, Muenster, Germany., Grünewald I; Gerhard-Domagk-Institute for Pathology, University Hospital Muenster, Muenster, Germany., Lindner LH; SarKUM, Department of Medicine III, Ludwig Maximilians University Hospital Großhadern, Munich, Germany., Di Gioia D; SarKUM, Department of Medicine III, Ludwig Maximilians University Hospital Großhadern, Munich, Germany., Hecker JS; Department of Medicine III, School of Medicine and Health and TranslaTUM Center for Translational Cancer Research, Technische Universitaet Muenchen, Munich, Germany., Maurer S; Department of Medicine III, School of Medicine and Health and TranslaTUM Center for Translational Cancer Research, Technische Universitaet Muenchen, Munich, Germany., Pink D; Department of Oncology and Palliative Care, HELIOS Klinikum Bad Saarow, Bad Saarow, Germany.; Department of Internal Medicine C, University Hospital Greifswald, Greifswald, Germany., Fried M; University Cancer Center Mainz (UCT Mainz) and Clinic and Polyclinic for Internal Medicine III, University Hospital Mainz, Mainz, Germany., Zapata Bonilla SA; University Cancer Center Mainz (UCT Mainz) and Clinic and Polyclinic for Internal Medicine III, University Hospital Mainz, Mainz, Germany., Scheuble AM; Department of Medicine (Oncology, Gastroenterology, Hepatology, Pulmonology), University of Leipzig Medical Center, Comprehensive Cancer Center Central Germany (CCCG), Leipzig, Germany., Lordick F; Department of Medicine (Oncology, Gastroenterology, Hepatology, Pulmonology), University of Leipzig Medical Center, Comprehensive Cancer Center Central Germany (CCCG), Leipzig, Germany., Ivanyi P; Department of Hematology and Oncology, Medizinische Hochschule Hannover, Hannover, Germany., Fobker M; Central Laboratory, University Hospital Muenster, Muenster, Germany., Lenz G; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital of Muenster, Albert‑Schweitzer‑Campus 1, 48149, Muenster, Germany., Gerss J; Institute of Biostatistics and Clinical Research, University of Muenster, Muenster, Germany., Kessler T; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital of Muenster, Albert‑Schweitzer‑Campus 1, 48149, Muenster, Germany., Berdel WE; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital of Muenster, Albert‑Schweitzer‑Campus 1, 48149, Muenster, Germany. berdel@uni-muenster.de., Schliemann C; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital of Muenster, Albert‑Schweitzer‑Campus 1, 48149, Muenster, Germany. Christoph.Schliemann@ukmuenster.de.
Source: Scientific reports [Sci Rep] 2026 Feb 19; Vol. 16 (1). Date of Electronic Publication: 2026 Feb 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Trabectedin plus CD13-targeted tissue factor tTF-NGR against advanced relapsed or refractory soft tissue sarcoma: translational data, clinical safety and efficacy.
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  Data: <searchLink fieldCode="AU" term="%22Hessling+K%22">Hessling K</searchLink>; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital of Muenster, Albert‑Schweitzer‑Campus 1, 48149, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Brand+C%22">Brand C</searchLink>; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital of Muenster, Albert‑Schweitzer‑Campus 1, 48149, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Schwöppe+C%22">Schwöppe C</searchLink>; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital of Muenster, Albert‑Schweitzer‑Campus 1, 48149, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Gerwing+M%22">Gerwing M</searchLink>; Department of Radiology, University Hospital Muenster, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Pavelka+S%22">Pavelka S</searchLink>; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital of Muenster, Albert‑Schweitzer‑Campus 1, 48149, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Berdel+AF%22">Berdel AF</searchLink>; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital of Muenster, Albert‑Schweitzer‑Campus 1, 48149, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Hintelmann+H%22">Hintelmann H</searchLink>; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital of Muenster, Albert‑Schweitzer‑Campus 1, 48149, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Hamacher+R%22">Hamacher R</searchLink>; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Müller-Tidow+C%22">Müller-Tidow C</searchLink>; Center for Internal Medicine 5, University Hospital Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Egerer+G%22">Egerer G</searchLink>; Center for Internal Medicine 5, University Hospital Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hartmann+W%22">Hartmann W</searchLink>; Gerhard-Domagk-Institute for Pathology, University Hospital Muenster, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Grünewald+I%22">Grünewald I</searchLink>; Gerhard-Domagk-Institute for Pathology, University Hospital Muenster, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Lindner+LH%22">Lindner LH</searchLink>; SarKUM, Department of Medicine III, Ludwig Maximilians University Hospital Großhadern, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Di+Gioia+D%22">Di Gioia D</searchLink>; SarKUM, Department of Medicine III, Ludwig Maximilians University Hospital Großhadern, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Hecker+JS%22">Hecker JS</searchLink>; Department of Medicine III, School of Medicine and Health and TranslaTUM Center for Translational Cancer Research, Technische Universitaet Muenchen, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Maurer+S%22">Maurer S</searchLink>; Department of Medicine III, School of Medicine and Health and TranslaTUM Center for Translational Cancer Research, Technische Universitaet Muenchen, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Pink+D%22">Pink D</searchLink>; Department of Oncology and Palliative Care, HELIOS Klinikum Bad Saarow, Bad Saarow, Germany.; Department of Internal Medicine C, University Hospital Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Fried+M%22">Fried M</searchLink>; University Cancer Center Mainz (UCT Mainz) and Clinic and Polyclinic for Internal Medicine III, University Hospital Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Zapata+Bonilla+SA%22">Zapata Bonilla SA</searchLink>; University Cancer Center Mainz (UCT Mainz) and Clinic and Polyclinic for Internal Medicine III, University Hospital Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Scheuble+AM%22">Scheuble AM</searchLink>; Department of Medicine (Oncology, Gastroenterology, Hepatology, Pulmonology), University of Leipzig Medical Center, Comprehensive Cancer Center Central Germany (CCCG), Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Lordick+F%22">Lordick F</searchLink>; Department of Medicine (Oncology, Gastroenterology, Hepatology, Pulmonology), University of Leipzig Medical Center, Comprehensive Cancer Center Central Germany (CCCG), Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Ivanyi+P%22">Ivanyi P</searchLink>; Department of Hematology and Oncology, Medizinische Hochschule Hannover, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Fobker+M%22">Fobker M</searchLink>; Central Laboratory, University Hospital Muenster, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Lenz+G%22">Lenz G</searchLink>; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital of Muenster, Albert‑Schweitzer‑Campus 1, 48149, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Gerss+J%22">Gerss J</searchLink>; Institute of Biostatistics and Clinical Research, University of Muenster, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Kessler+T%22">Kessler T</searchLink>; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital of Muenster, Albert‑Schweitzer‑Campus 1, 48149, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Berdel+WE%22">Berdel WE</searchLink>; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital of Muenster, Albert‑Schweitzer‑Campus 1, 48149, Muenster, Germany. berdel@uni-muenster.de.<br /><searchLink fieldCode="AU" term="%22Schliemann+C%22">Schliemann C</searchLink>; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital of Muenster, Albert‑Schweitzer‑Campus 1, 48149, Muenster, Germany. Christoph.Schliemann@ukmuenster.de.
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