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Conserved CD4+ T cell staphylococcal and streptococcal epitopes enable broad-acting vaccines in mice.

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Title: Conserved CD4+ T cell staphylococcal and streptococcal epitopes enable broad-acting vaccines in mice.
Authors: Braverman J; Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia., Monk IR; Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia., Turner AM; Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia., Braun A; Department of Biochemistry and Molecular Biology, Immunity Program, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia., Zhang H; Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia., Chung S; Department of Biochemistry and Molecular Biology, Immunity Program, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia., Jones CM; Department of Biochemistry and Molecular Biology, Immunity Program, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia., Zareie P; Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.; Department of Biochemistry and Molecular Biology, Immunity Program, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia., La Gruta NL; Department of Biochemistry and Molecular Biology, Immunity Program, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia., Rimmer J; Department of Otolaryngology Head & Neck Surgery, Monash Health, Melbourne, Victoria, Australia.; Department of Surgery, Monash University, Melbourne, Victoria, Australia., Carter GP; Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia., Howden BP; Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.; Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.; Department of Infectious Diseases and Immunology, Austin Health, Melbourne, Victoria, Australia.; Centre for Pathogen Genomics, The University of Melbourne, Melbourne, Victoria, Australia., Wang N; Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.; Enteric Diseases Research Group, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.; Department of Paediatrics, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia., Purcell AW; Department of Biochemistry and Molecular Biology, Immunity Program, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia., Stinear TP; Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.; Centre for Pathogen Genomics, The University of Melbourne, Melbourne, Victoria, Australia., Wakim LM; Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia. wakiml@unimelb.edu.au.
Source: Nature microbiology [Nat Microbiol] 2026 Mar; Vol. 11 (3), pp. 731-746. Date of Electronic Publication: 2026 Feb 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE
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  Data: Conserved CD4<superscript>+</superscript> T cell staphylococcal and streptococcal epitopes enable broad-acting vaccines in mice.
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  Data: <searchLink fieldCode="AU" term="%22Braverman+J%22">Braverman J</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Monk+IR%22">Monk IR</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Turner+AM%22">Turner AM</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Braun+A%22">Braun A</searchLink>; Department of Biochemistry and Molecular Biology, Immunity Program, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Chung+S%22">Chung S</searchLink>; Department of Biochemistry and Molecular Biology, Immunity Program, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Jones+CM%22">Jones CM</searchLink>; Department of Biochemistry and Molecular Biology, Immunity Program, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Zareie+P%22">Zareie P</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.; Department of Biochemistry and Molecular Biology, Immunity Program, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22La+Gruta+NL%22">La Gruta NL</searchLink>; Department of Biochemistry and Molecular Biology, Immunity Program, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Rimmer+J%22">Rimmer J</searchLink>; Department of Otolaryngology Head & Neck Surgery, Monash Health, Melbourne, Victoria, Australia.; Department of Surgery, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Carter+GP%22">Carter GP</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Howden+BP%22">Howden BP</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.; Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.; Department of Infectious Diseases and Immunology, Austin Health, Melbourne, Victoria, Australia.; Centre for Pathogen Genomics, The University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Wang+N%22">Wang N</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.; Enteric Diseases Research Group, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.; Department of Paediatrics, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Purcell+AW%22">Purcell AW</searchLink>; Department of Biochemistry and Molecular Biology, Immunity Program, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Stinear+TP%22">Stinear TP</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.; Centre for Pathogen Genomics, The University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Wakim+LM%22">Wakim LM</searchLink>; Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia. wakiml@unimelb.edu.au.
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