A novel aurora kinase molecular glue-based degrader sp-2-067 inhibits prostate cancer cell growth and alters immune profile.
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| Title: | A novel aurora kinase molecular glue-based degrader sp-2-067 inhibits prostate cancer cell growth and alters immune profile. |
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| Authors: | Shukla S; University of FL - Jacksonville, 653 West 8Th Street, Jacksonville, FL, 32209, USA., Pogash S; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20, N. Pine St., Baltimore, MD, 21201, USA., Venkatesh A; University of FL - Jacksonville, 653 West 8Th Street, Jacksonville, FL, 32209, USA.; George's University, St. George, Grenada., McGrath J; University of FL - Jacksonville, 653 West 8Th Street, Jacksonville, FL, 32209, USA., Rosales RDR; University of FL - Jacksonville, 653 West 8Th Street, Jacksonville, FL, 32209, USA., Kanumuambidi JP; University of FL - Jacksonville, 653 West 8Th Street, Jacksonville, FL, 32209, USA., Al-Toubat M; University of FL - Jacksonville, 653 West 8Th Street, Jacksonville, FL, 32209, USA., Fletcher S; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20, N. Pine St., Baltimore, MD, 21201, USA., Balaji KC; University of FL - Jacksonville, 653 West 8Th Street, Jacksonville, FL, 32209, USA. kc.balaji@jax.ufl.edu. |
| Source: | Investigational new drugs [Invest New Drugs] 2026 Feb; Vol. 44 (1), pp. 56-63. Date of Electronic Publication: 2026 Feb 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Country of Publication: United States NLM ID: 8309330 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-0646 (Electronic) Linking ISSN: 01676997 NLM ISO Abbreviation: Invest New Drugs Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41721176 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A novel aurora kinase molecular glue-based degrader sp-2-067 inhibits prostate cancer cell growth and alters immune profile. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Shukla+S%22">Shukla S</searchLink>; University of FL - Jacksonville, 653 West 8Th Street, Jacksonville, FL, 32209, USA.<br /><searchLink fieldCode="AU" term="%22Pogash+S%22">Pogash S</searchLink>; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20, N. Pine St., Baltimore, MD, 21201, USA.<br /><searchLink fieldCode="AU" term="%22Venkatesh+A%22">Venkatesh A</searchLink>; University of FL - Jacksonville, 653 West 8Th Street, Jacksonville, FL, 32209, USA.; George's University, St. George, Grenada.<br /><searchLink fieldCode="AU" term="%22McGrath+J%22">McGrath J</searchLink>; University of FL - Jacksonville, 653 West 8Th Street, Jacksonville, FL, 32209, USA.<br /><searchLink fieldCode="AU" term="%22Rosales+RDR%22">Rosales RDR</searchLink>; University of FL - Jacksonville, 653 West 8Th Street, Jacksonville, FL, 32209, USA.<br /><searchLink fieldCode="AU" term="%22Kanumuambidi+JP%22">Kanumuambidi JP</searchLink>; University of FL - Jacksonville, 653 West 8Th Street, Jacksonville, FL, 32209, USA.<br /><searchLink fieldCode="AU" term="%22Al-Toubat+M%22">Al-Toubat M</searchLink>; University of FL - Jacksonville, 653 West 8Th Street, Jacksonville, FL, 32209, USA.<br /><searchLink fieldCode="AU" term="%22Fletcher+S%22">Fletcher S</searchLink>; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20, N. Pine St., Baltimore, MD, 21201, USA.<br /><searchLink fieldCode="AU" term="%22Balaji+KC%22">Balaji KC</searchLink>; University of FL - Jacksonville, 653 West 8Th Street, Jacksonville, FL, 32209, USA. kc.balaji@jax.ufl.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%228309330%22">Investigational new drugs</searchLink> [Invest New Drugs] 2026 Feb; Vol. 44 (1), pp. 56-63. <i>Date of Electronic Publication: </i>2026 Feb 21. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8309330 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-0646 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201676997%22">01676997 </searchLink><i>NLM ISO Abbreviation: </i>Invest New Drugs <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41721176 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10637-026-01603-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 56 Titles: – TitleFull: A novel aurora kinase molecular glue-based degrader sp-2-067 inhibits prostate cancer cell growth and alters immune profile. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Shukla S – PersonEntity: Name: NameFull: Pogash S – PersonEntity: Name: NameFull: Venkatesh A – PersonEntity: Name: NameFull: McGrath J – PersonEntity: Name: NameFull: Rosales RDR – PersonEntity: Name: NameFull: Kanumuambidi JP – PersonEntity: Name: NameFull: Al-Toubat M – PersonEntity: Name: NameFull: Fletcher S – PersonEntity: Name: NameFull: Balaji KC IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: 2026 Feb Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1573-0646 Numbering: – Type: volume Value: 44 – Type: issue Value: 1 Titles: – TitleFull: Investigational new drugs Type: main |
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