α-ketoglutarate/succinate ratio imbalance impairs thymine DNA glycosylase function and base excision repair process increasing susceptibility to pancreatic cancer.
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| Title: | α-ketoglutarate/succinate ratio imbalance impairs thymine DNA glycosylase function and base excision repair process increasing susceptibility to pancreatic cancer. |
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| Authors: | Malatesta S; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University, Rome, Italy.; Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University, Rome, Italy., Vigiano Benedetti V; Department of Translational Medicine, Catholic University of the Sacred Heart, Rome, Italy., Salviati E; Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy., Illi B; Institute of Molecular Biology and Pathology, National Research Council (IBPM-CNR), Rome, Italy., Manni I; SAFU Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Middonti E; Department of Oncology, University of Torino, Orbassano, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Rampioni Vinciguerra GL; Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sant'Andrea Hospital, Sapienza University, Rome, Italy., Licursi V; Institute of Molecular Biology and Pathology, National Research Council (IBPM-CNR), Rome, Italy., Troilo F; Institute of Molecular Biology and Pathology, National Research Council (IBPM-CNR), Rome, Italy., Colotti G; Institute of Molecular Biology and Pathology, National Research Council (IBPM-CNR), Rome, Italy., Cipolla L; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (IGM-CNR), Pavia, Italy., Sabbioneda S; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (IGM-CNR), Pavia, Italy., Perfetto L; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University, Rome, Italy., Piaggio G; SAFU Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Bussolino F; Department of Oncology, University of Torino, Orbassano, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Di Nicolantonio F; Department of Oncology, University of Torino, Orbassano, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Campiglia P; Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy., Sommella EM; Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy., Mori M; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy., Cencioni C; Institute of System Analysis and Informatics 'Antonio Ruberti', National Research Council (IASI-CNR), Rome, Italy. chiara.cencioni@cnr.it., Spallotta F; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University, Rome, Italy. francesco.spallotta@uniroma1.it.; Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University, Rome, Italy. francesco.spallotta@uniroma1.it. |
| Source: | Cell death & disease [Cell Death Dis] 2026 Feb 21; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-4889 |
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| DOI: | 10.1038/s41419-026-08475-w |
