α-ketoglutarate/succinate ratio imbalance impairs thymine DNA glycosylase function and base excision repair process increasing susceptibility to pancreatic cancer.
Saved in:
| Title: | α-ketoglutarate/succinate ratio imbalance impairs thymine DNA glycosylase function and base excision repair process increasing susceptibility to pancreatic cancer. |
|---|---|
| Authors: | Malatesta S; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University, Rome, Italy.; Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University, Rome, Italy., Vigiano Benedetti V; Department of Translational Medicine, Catholic University of the Sacred Heart, Rome, Italy., Salviati E; Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy., Illi B; Institute of Molecular Biology and Pathology, National Research Council (IBPM-CNR), Rome, Italy., Manni I; SAFU Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Middonti E; Department of Oncology, University of Torino, Orbassano, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Rampioni Vinciguerra GL; Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sant'Andrea Hospital, Sapienza University, Rome, Italy., Licursi V; Institute of Molecular Biology and Pathology, National Research Council (IBPM-CNR), Rome, Italy., Troilo F; Institute of Molecular Biology and Pathology, National Research Council (IBPM-CNR), Rome, Italy., Colotti G; Institute of Molecular Biology and Pathology, National Research Council (IBPM-CNR), Rome, Italy., Cipolla L; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (IGM-CNR), Pavia, Italy., Sabbioneda S; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (IGM-CNR), Pavia, Italy., Perfetto L; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University, Rome, Italy., Piaggio G; SAFU Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Bussolino F; Department of Oncology, University of Torino, Orbassano, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Di Nicolantonio F; Department of Oncology, University of Torino, Orbassano, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Campiglia P; Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy., Sommella EM; Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy., Mori M; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy., Cencioni C; Institute of System Analysis and Informatics 'Antonio Ruberti', National Research Council (IASI-CNR), Rome, Italy. chiara.cencioni@cnr.it., Spallotta F; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University, Rome, Italy. francesco.spallotta@uniroma1.it.; Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University, Rome, Italy. francesco.spallotta@uniroma1.it. |
| Source: | Cell death & disease [Cell Death Dis] 2026 Feb 21; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
|
Full text is not displayed to guests.
Login for full access.
|
|
| FullText | Links: – Type: pdflink Text: Availability: 1 |
|---|---|
| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41723136 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: α-ketoglutarate/succinate ratio imbalance impairs thymine DNA glycosylase function and base excision repair process increasing susceptibility to pancreatic cancer. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Malatesta+S%22">Malatesta S</searchLink>; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University, Rome, Italy.; Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Vigiano+Benedetti+V%22">Vigiano Benedetti V</searchLink>; Department of Translational Medicine, Catholic University of the Sacred Heart, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Salviati+E%22">Salviati E</searchLink>; Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy.<br /><searchLink fieldCode="AU" term="%22Illi+B%22">Illi B</searchLink>; Institute of Molecular Biology and Pathology, National Research Council (IBPM-CNR), Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Manni+I%22">Manni I</searchLink>; SAFU Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Middonti+E%22">Middonti E</searchLink>; Department of Oncology, University of Torino, Orbassano, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Rampioni+Vinciguerra+GL%22">Rampioni Vinciguerra GL</searchLink>; Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sant'Andrea Hospital, Sapienza University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Licursi+V%22">Licursi V</searchLink>; Institute of Molecular Biology and Pathology, National Research Council (IBPM-CNR), Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Troilo+F%22">Troilo F</searchLink>; Institute of Molecular Biology and Pathology, National Research Council (IBPM-CNR), Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Colotti+G%22">Colotti G</searchLink>; Institute of Molecular Biology and Pathology, National Research Council (IBPM-CNR), Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Cipolla+L%22">Cipolla L</searchLink>; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (IGM-CNR), Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Sabbioneda+S%22">Sabbioneda S</searchLink>; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (IGM-CNR), Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Perfetto+L%22">Perfetto L</searchLink>; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Piaggio+G%22">Piaggio G</searchLink>; SAFU Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Bussolino+F%22">Bussolino F</searchLink>; Department of Oncology, University of Torino, Orbassano, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Nicolantonio+F%22">Di Nicolantonio F</searchLink>; Department of Oncology, University of Torino, Orbassano, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Campiglia+P%22">Campiglia P</searchLink>; Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy.<br /><searchLink fieldCode="AU" term="%22Sommella+EM%22">Sommella EM</searchLink>; Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy.<br /><searchLink fieldCode="AU" term="%22Mori+M%22">Mori M</searchLink>; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Cencioni+C%22">Cencioni C</searchLink>; Institute of System Analysis and Informatics 'Antonio Ruberti', National Research Council (IASI-CNR), Rome, Italy. chiara.cencioni@cnr.it.<br /><searchLink fieldCode="AU" term="%22Spallotta+F%22">Spallotta F</searchLink>; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University, Rome, Italy. francesco.spallotta@uniroma1.it.; Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University, Rome, Italy. francesco.spallotta@uniroma1.it. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2026 Feb 21; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Feb 21. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101524092 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-4889 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Death Dis <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41723136 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41419-026-08475-w Languages: – Code: eng Text: English Titles: – TitleFull: α-ketoglutarate/succinate ratio imbalance impairs thymine DNA glycosylase function and base excision repair process increasing susceptibility to pancreatic cancer. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Malatesta S – PersonEntity: Name: NameFull: Vigiano Benedetti V – PersonEntity: Name: NameFull: Salviati E – PersonEntity: Name: NameFull: Illi B – PersonEntity: Name: NameFull: Manni I – PersonEntity: Name: NameFull: Middonti E – PersonEntity: Name: NameFull: Rampioni Vinciguerra GL – PersonEntity: Name: NameFull: Licursi V – PersonEntity: Name: NameFull: Troilo F – PersonEntity: Name: NameFull: Colotti G – PersonEntity: Name: NameFull: Cipolla L – PersonEntity: Name: NameFull: Sabbioneda S – PersonEntity: Name: NameFull: Perfetto L – PersonEntity: Name: NameFull: Piaggio G – PersonEntity: Name: NameFull: Bussolino F – PersonEntity: Name: NameFull: Di Nicolantonio F – PersonEntity: Name: NameFull: Campiglia P – PersonEntity: Name: NameFull: Sommella EM – PersonEntity: Name: NameFull: Mori M – PersonEntity: Name: NameFull: Cencioni C – PersonEntity: Name: NameFull: Spallotta F IsPartOfRelationships: – BibEntity: Dates: – D: 21 M: 02 Text: 2026 Feb 21 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2041-4889 Numbering: – Type: volume Value: 17 – Type: issue Value: 1 Titles: – TitleFull: Cell death & disease Type: main |
| ResultId | 1 |
