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JAK2/STAT3-dependent regulation of MDM4/MDM2-p53 signaling in methotrexate-induced ferroptosis and nephrotoxicity.

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Title: JAK2/STAT3-dependent regulation of MDM4/MDM2-p53 signaling in methotrexate-induced ferroptosis and nephrotoxicity.
Authors: Cheng Y; Department of Pharmacy, Shengjing Hospital Affiliated to China Medical University, 36 Sanhao Street, Shenyang, 110004, Liaoning Province, China.; Department of Pharmacy, Fujian Medical University Union Hospital, 29 Xin Quan Rd, Fuzhou, 350001, Fujian Province, China., Zhao M; Department of Pharmacy, Shengjing Hospital Affiliated to China Medical University, 36 Sanhao Street, Shenyang, 110004, Liaoning Province, China., Zhang Y; Department of Pharmacy, Shengjing Hospital Affiliated to China Medical University, 36 Sanhao Street, Shenyang, 110004, Liaoning Province, China., Liu M; Department of Pharmacy, Fujian Medical University Union Hospital, 29 Xin Quan Rd, Fuzhou, 350001, Fujian Province, China. liumb0591@fjmu.edu.cn., Zhao L; Department of Pharmacy, Shengjing Hospital Affiliated to China Medical University, 36 Sanhao Street, Shenyang, 110004, Liaoning Province, China. mlzhao@cmu.edu.cn.
Source: Archives of pharmacal research [Arch Pharm Res] 2026 Feb; Vol. 49 (2), pp. 223-241. Date of Electronic Publication: 2026 Feb 22.
Publication Type: Journal Article
Journal Info: Publisher: Pharmaceutical Society of Korea Country of Publication: Korea (South) NLM ID: 8000036 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1976-3786 (Electronic) Linking ISSN: 02536269 NLM ISO Abbreviation: Arch Pharm Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: JAK2/STAT3-dependent regulation of MDM4/MDM2-p53 signaling in methotrexate-induced ferroptosis and nephrotoxicity.
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  Data: <searchLink fieldCode="AU" term="%22Cheng+Y%22">Cheng Y</searchLink>; Department of Pharmacy, Shengjing Hospital Affiliated to China Medical University, 36 Sanhao Street, Shenyang, 110004, Liaoning Province, China.; Department of Pharmacy, Fujian Medical University Union Hospital, 29 Xin Quan Rd, Fuzhou, 350001, Fujian Province, China.<br /><searchLink fieldCode="AU" term="%22Zhao+M%22">Zhao M</searchLink>; Department of Pharmacy, Shengjing Hospital Affiliated to China Medical University, 36 Sanhao Street, Shenyang, 110004, Liaoning Province, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Pharmacy, Shengjing Hospital Affiliated to China Medical University, 36 Sanhao Street, Shenyang, 110004, Liaoning Province, China.<br /><searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; Department of Pharmacy, Fujian Medical University Union Hospital, 29 Xin Quan Rd, Fuzhou, 350001, Fujian Province, China. liumb0591@fjmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhao+L%22">Zhao L</searchLink>; Department of Pharmacy, Shengjing Hospital Affiliated to China Medical University, 36 Sanhao Street, Shenyang, 110004, Liaoning Province, China. mlzhao@cmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%228000036%22">Archives of pharmacal research</searchLink> [Arch Pharm Res] 2026 Feb; Vol. 49 (2), pp. 223-241. <i>Date of Electronic Publication: </i>2026 Feb 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Pharmaceutical+Society+of+Korea%22">Pharmaceutical Society of Korea </searchLink><i>Country of Publication: </i>Korea (South) <i>NLM ID: </i>8000036 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1976-3786 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202536269%22">02536269 </searchLink><i>NLM ISO Abbreviation: </i>Arch Pharm Res <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s12272-026-01599-9
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      – Code: eng
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      – TitleFull: JAK2/STAT3-dependent regulation of MDM4/MDM2-p53 signaling in methotrexate-induced ferroptosis and nephrotoxicity.
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              Text: 2026 Feb
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              Y: 2026
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