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PDHA1-acetylation signaling suppresses cuproptosis to attenuate anti-androgen effect in prostate cancer.

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Title: PDHA1-acetylation signaling suppresses cuproptosis to attenuate anti-androgen effect in prostate cancer.
Authors: Zhuang R; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.; Department of Urology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in Southern China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China., Zhou Q; Department of Urology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in Southern China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, China., Cheng B; Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, China., Peng S; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China., Xiong Z; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China., Xie Z; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China., Lin W; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China., Su T; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China., Li Z; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China., Yao K; Department of Urology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in Southern China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, China., Wu Z; Department of Urology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in Southern China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, China. wuzhim@sysucc.org.cn., Huang H; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. huangh9@mail.sysu.edu.cn.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. huangh9@mail.sysu.edu.cn.; Guangdong Provincial Clinical Research Center for Urological Diseases, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. huangh9@mail.sysu.edu.cn.; Department of Urology, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, Guangdong, China. huangh9@mail.sysu.edu.cn., Li K; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. likw6@mail.sysu.edu.cn.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. likw6@mail.sysu.edu.cn.; Guangdong Provincial Clinical Research Center for Urological Diseases, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. likw6@mail.sysu.edu.cn.
Source: Cell death & disease [Cell Death Dis] 2026 Feb 23; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
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  Data: PDHA1-acetylation signaling suppresses cuproptosis to attenuate anti-androgen effect in prostate cancer.
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  Data: <searchLink fieldCode="AU" term="%22Zhuang+R%22">Zhuang R</searchLink>; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.; Department of Urology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in Southern China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhou+Q%22">Zhou Q</searchLink>; Department of Urology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in Southern China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Cheng+B%22">Cheng B</searchLink>; Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Peng+S%22">Peng S</searchLink>; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xiong+Z%22">Xiong Z</searchLink>; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xie+Z%22">Xie Z</searchLink>; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Lin+W%22">Lin W</searchLink>; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Su+T%22">Su T</searchLink>; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Yao+K%22">Yao K</searchLink>; Department of Urology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in Southern China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wu+Z%22">Wu Z</searchLink>; Department of Urology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in Southern China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, China. wuzhim@sysucc.org.cn.<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. huangh9@mail.sysu.edu.cn.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. huangh9@mail.sysu.edu.cn.; Guangdong Provincial Clinical Research Center for Urological Diseases, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. huangh9@mail.sysu.edu.cn.; Department of Urology, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, Guangdong, China. huangh9@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Li+K%22">Li K</searchLink>; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. likw6@mail.sysu.edu.cn.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. likw6@mail.sysu.edu.cn.; Guangdong Provincial Clinical Research Center for Urological Diseases, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. likw6@mail.sysu.edu.cn.
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