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A reduced TBX5-dependent gene regulatory network links atrial fibrillation and heart failure.

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Title: A reduced TBX5-dependent gene regulatory network links atrial fibrillation and heart failure.
Authors: Lazarevic S; Department of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL, USA., Perez-Cervantes C; Department of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL, USA., Wang Z; Department of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL, USA., Shen KM; Department of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL, USA., Gadek M; Department of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL, USA., Xiao J; Leon H. Charney Division of Cardiology, New York University Langone Health, New York, NY, USA., Yamaguchi N; Leon H. Charney Division of Cardiology, New York University Langone Health, New York, NY, USA., Hall JM; Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL, USA., Koca Y; Department of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL, USA., Chapski DJ; Departments of Anesthesiology & Perioperative Medicine, Medicine and Physiology, Molecular Biology Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Rosa-Garrido M; Department of Cellular and Molecular Signaling, The Institute of Biomedicine and Biotechnology of Cantabria, CSIC-University of Cantabria, Santander, Spain., Rubino M; Department of Medicine, Division of Cardiology and Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Nadadur RD; Department of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL, USA., McKinsey TA; Department of Medicine, Division of Cardiology and Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Vondriska TM; Departments of Anesthesiology & Perioperative Medicine, Medicine and Physiology, Molecular Biology Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Ruthenburg AJ; Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL, USA., Pott S; Department of Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, USA., Park DS; Leon H. Charney Division of Cardiology, New York University Langone Health, New York, NY, USA., Moskowitz IP; Department of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL, USA. imoskowitz@uchicago.edu.
Source: Nature cardiovascular research [Nat Cardiovasc Res] 2026 Feb; Vol. 5 (2), pp. 96-117. Date of Electronic Publication: 2026 Feb 23.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 9918284280206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2731-0590 (Electronic) Linking ISSN: 27310590 NLM ISO Abbreviation: Nat Cardiovasc Res Subsets: MEDLINE
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  Data: A reduced TBX5-dependent gene regulatory network links atrial fibrillation and heart failure.
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  Data: <searchLink fieldCode="AU" term="%22Lazarevic+S%22">Lazarevic S</searchLink>; Department of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Perez-Cervantes+C%22">Perez-Cervantes C</searchLink>; Department of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Shen+KM%22">Shen KM</searchLink>; Department of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Gadek+M%22">Gadek M</searchLink>; Department of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Xiao+J%22">Xiao J</searchLink>; Leon H. Charney Division of Cardiology, New York University Langone Health, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Yamaguchi+N%22">Yamaguchi N</searchLink>; Leon H. Charney Division of Cardiology, New York University Langone Health, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hall+JM%22">Hall JM</searchLink>; Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Koca+Y%22">Koca Y</searchLink>; Department of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Chapski+DJ%22">Chapski DJ</searchLink>; Departments of Anesthesiology & Perioperative Medicine, Medicine and Physiology, Molecular Biology Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rosa-Garrido+M%22">Rosa-Garrido M</searchLink>; Department of Cellular and Molecular Signaling, The Institute of Biomedicine and Biotechnology of Cantabria, CSIC-University of Cantabria, Santander, Spain.<br /><searchLink fieldCode="AU" term="%22Rubino+M%22">Rubino M</searchLink>; Department of Medicine, Division of Cardiology and Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Nadadur+RD%22">Nadadur RD</searchLink>; Department of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22McKinsey+TA%22">McKinsey TA</searchLink>; Department of Medicine, Division of Cardiology and Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Vondriska+TM%22">Vondriska TM</searchLink>; Departments of Anesthesiology & Perioperative Medicine, Medicine and Physiology, Molecular Biology Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ruthenburg+AJ%22">Ruthenburg AJ</searchLink>; Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Pott+S%22">Pott S</searchLink>; Department of Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Park+DS%22">Park DS</searchLink>; Leon H. Charney Division of Cardiology, New York University Langone Health, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Moskowitz+IP%22">Moskowitz IP</searchLink>; Department of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL, USA. imoskowitz@uchicago.edu.
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  Data: <searchLink fieldCode="JN" term="%229918284280206676%22">Nature cardiovascular research</searchLink> [Nat Cardiovasc Res] 2026 Feb; Vol. 5 (2), pp. 96-117. <i>Date of Electronic Publication: </i>2026 Feb 23.
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