The immunometabolic topography of cellular organization and bacterial control in tuberculosis granulomas.

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Title: The immunometabolic topography of cellular organization and bacterial control in tuberculosis granulomas.
Authors: McCaffrey EF; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. erin.mccaffrey@nih.gov.; Spatial Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA. erin.mccaffrey@nih.gov., Delmastro AC; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Fitzhugh I; The Department of Biomedical Sciences and Technology, AdventHealth University, Orlando, FL, USA., Ranek JS; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Douglas S; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Peters JM; Department of Biological Engineering, MIT, Cambridge, MA, USA.; Ragon Institute of Mass General, Harvard, and MIT, Cambridge, MA, USA., Fullaway CC; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Bosse M; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Liu CC; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Gillen C; The Department of Biomedical Sciences and Technology, AdventHealth University, Orlando, FL, USA., Greenwald NF; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Anzick S; Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT, USA., Martens C; Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT, USA., Winfree S; Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT, USA., Bai Y; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Sowers C; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Goldston M; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Kong A; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Boonrat P; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Bigbee CL; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Venugopalan R; Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA., Maiello P; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Klein E; Division of Laboratory Animal Research, University of Pittsburgh, Pittsburgh, PA, USA., Rodgers MA; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Scanga CA; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Lin PL; Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Pediatrics, Division of Infectious Disease, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Bendall SC; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Kirschner DE; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA., Fortune SM; Ragon Institute of Mass General, Harvard, and MIT, Cambridge, MA, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Bryson BD; Department of Biological Engineering, MIT, Cambridge, MA, USA.; Ragon Institute of Mass General, Harvard, and MIT, Cambridge, MA, USA., Butler JR; The Department of Biomedical Sciences and Technology, AdventHealth University, Orlando, FL, USA., Mattila JT; Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA., Flynn JL; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Angelo M; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. mangelo0@stanford.edu.
Source: Nature immunology [Nat Immunol] 2026 Apr; Vol. 27 (4), pp. 867-880. Date of Electronic Publication: 2026 Feb 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1529-2916
DOI:10.1038/s41590-026-02431-8