Non-cytolytic re-engineering of a viral vaccine vector enables durable effector-memory T cell immunity by reinforcing type I IFN induction.

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Title: Non-cytolytic re-engineering of a viral vaccine vector enables durable effector-memory T cell immunity by reinforcing type I IFN induction.
Authors: Ciancaglini M; Department of Biomedicine, Division of Experimental Virology, University of Basel, 4009 Basel, Switzerland., Avanthay R; Institute of Virology and Immunology, 3147 Mittelhäusern, Switzerland.; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland., Marx AF; Department of Biomedicine, Division of Experimental Virology, University of Basel, 4009 Basel, Switzerland., Abreu-Mota T; Department of Biomedicine, Division of Experimental Virology, University of Basel, 4009 Basel, Switzerland., Finozzi D; Department of Biomedicine, Division of Experimental Virology, University of Basel, 4009 Basel, Switzerland., Fixemer J; Department of Biomedicine, Division of Experimental Virology, University of Basel, 4009 Basel, Switzerland., Geier F; Department of Biomedicine, Bioinformatics Core Facility, University of Basel, 4031 Basel, Switzerland.; Swiss Institute of Bioinformatics, Basel, Switzerland., Burri D; Department of Biomedicine, Bioinformatics Core Facility, University of Basel, 4031 Basel, Switzerland.; Swiss Institute of Bioinformatics, Basel, Switzerland., Wagner I; Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland., Vincenti I; Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland., Kreuzfeldt M; Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland.; Division of Clinical Pathology, Geneva University Hospital, 1206 Geneva, Switzerland., Merkler D; Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland.; Division of Clinical Pathology, Geneva University Hospital, 1206 Geneva, Switzerland., Zimmer G; Institute of Virology and Immunology, 3147 Mittelhäusern, Switzerland.; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland., Pinschewer DD; Department of Biomedicine, Division of Experimental Virology, University of Basel, 4009 Basel, Switzerland.
Source: Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2026 Feb 02; Vol. 37 (1), pp. 102852. Date of Electronic Publication: 2026 Feb 02 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101581621 Publication Model: eCollection Cited Medium: Print ISSN: 2162-2531 (Print) Linking ISSN: 21622531 NLM ISO Abbreviation: Mol Ther Nucleic Acids Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2162-2531
DOI:10.1016/j.omtn.2026.102852