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Non-cytolytic re-engineering of a viral vaccine vector enables durable effector-memory T cell immunity by reinforcing type I IFN induction.

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Title: Non-cytolytic re-engineering of a viral vaccine vector enables durable effector-memory T cell immunity by reinforcing type I IFN induction.
Authors: Ciancaglini M; Department of Biomedicine, Division of Experimental Virology, University of Basel, 4009 Basel, Switzerland., Avanthay R; Institute of Virology and Immunology, 3147 Mittelhäusern, Switzerland.; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland., Marx AF; Department of Biomedicine, Division of Experimental Virology, University of Basel, 4009 Basel, Switzerland., Abreu-Mota T; Department of Biomedicine, Division of Experimental Virology, University of Basel, 4009 Basel, Switzerland., Finozzi D; Department of Biomedicine, Division of Experimental Virology, University of Basel, 4009 Basel, Switzerland., Fixemer J; Department of Biomedicine, Division of Experimental Virology, University of Basel, 4009 Basel, Switzerland., Geier F; Department of Biomedicine, Bioinformatics Core Facility, University of Basel, 4031 Basel, Switzerland.; Swiss Institute of Bioinformatics, Basel, Switzerland., Burri D; Department of Biomedicine, Bioinformatics Core Facility, University of Basel, 4031 Basel, Switzerland.; Swiss Institute of Bioinformatics, Basel, Switzerland., Wagner I; Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland., Vincenti I; Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland., Kreuzfeldt M; Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland.; Division of Clinical Pathology, Geneva University Hospital, 1206 Geneva, Switzerland., Merkler D; Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland.; Division of Clinical Pathology, Geneva University Hospital, 1206 Geneva, Switzerland., Zimmer G; Institute of Virology and Immunology, 3147 Mittelhäusern, Switzerland.; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland., Pinschewer DD; Department of Biomedicine, Division of Experimental Virology, University of Basel, 4009 Basel, Switzerland.
Source: Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2026 Feb 02; Vol. 37 (1), pp. 102852. Date of Electronic Publication: 2026 Feb 02 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101581621 Publication Model: eCollection Cited Medium: Print ISSN: 2162-2531 (Print) Linking ISSN: 21622531 NLM ISO Abbreviation: Mol Ther Nucleic Acids Subsets: PubMed not MEDLINE
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  Data: Non-cytolytic re-engineering of a viral vaccine vector enables durable effector-memory T cell immunity by reinforcing type I IFN induction.
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  Data: <searchLink fieldCode="AU" term="%22Ciancaglini+M%22">Ciancaglini M</searchLink>; Department of Biomedicine, Division of Experimental Virology, University of Basel, 4009 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Avanthay+R%22">Avanthay R</searchLink>; Institute of Virology and Immunology, 3147 Mittelhäusern, Switzerland.; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Marx+AF%22">Marx AF</searchLink>; Department of Biomedicine, Division of Experimental Virology, University of Basel, 4009 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Abreu-Mota+T%22">Abreu-Mota T</searchLink>; Department of Biomedicine, Division of Experimental Virology, University of Basel, 4009 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Finozzi+D%22">Finozzi D</searchLink>; Department of Biomedicine, Division of Experimental Virology, University of Basel, 4009 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Fixemer+J%22">Fixemer J</searchLink>; Department of Biomedicine, Division of Experimental Virology, University of Basel, 4009 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Geier+F%22">Geier F</searchLink>; Department of Biomedicine, Bioinformatics Core Facility, University of Basel, 4031 Basel, Switzerland.; Swiss Institute of Bioinformatics, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Burri+D%22">Burri D</searchLink>; Department of Biomedicine, Bioinformatics Core Facility, University of Basel, 4031 Basel, Switzerland.; Swiss Institute of Bioinformatics, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wagner+I%22">Wagner I</searchLink>; Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Vincenti+I%22">Vincenti I</searchLink>; Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kreuzfeldt+M%22">Kreuzfeldt M</searchLink>; Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland.; Division of Clinical Pathology, Geneva University Hospital, 1206 Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Merkler+D%22">Merkler D</searchLink>; Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland.; Division of Clinical Pathology, Geneva University Hospital, 1206 Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Zimmer+G%22">Zimmer G</searchLink>; Institute of Virology and Immunology, 3147 Mittelhäusern, Switzerland.; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pinschewer+DD%22">Pinschewer DD</searchLink>; Department of Biomedicine, Division of Experimental Virology, University of Basel, 4009 Basel, Switzerland.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101581621 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>2162-2531 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221622531%22">21622531 </searchLink><i>NLM ISO Abbreviation: </i>Mol Ther Nucleic Acids <i>Subsets: </i>PubMed not MEDLINE
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