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Interrogating the immune landscape of microsatellite stable RAS-mutated colon cancer.

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Title: Interrogating the immune landscape of microsatellite stable RAS-mutated colon cancer.
Authors: Dienstmann R; Oncology Data Science (ODysSey) Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.; University of Vic-Central University of Catalonia, Spain., García-Galea E; Oncology Data Science (ODysSey) Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., O'Farrell A; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland., Kinsella Z; School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland., Meylan M; Centre de Recherche des Cordeliers, INSERM 1138, Sorbonne Université, Université Paris Cité, France., Petitprez F; Centre de Recherche des Cordeliers, INSERM 1138, Sorbonne Université, Université Paris Cité, France., Arijs I; VIB Centre for Cancer Biology, Leuven, Belgium.; Laboratory for Translational Genetics, Department of Human Genetics, Leuven, Belgium., Venken T; VIB Centre for Cancer Biology, Leuven, Belgium.; Laboratory for Translational Genetics, Department of Human Genetics, Leuven, Belgium., Ps H; Division of Cancer Biology, The Institute of Cancer Research, London, UK., Lärkeryd A; Data Science & AI, The Centre for Immunotherapy of Cancer, Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK., Miller I; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland., Selves J; Department of Pathology, Institut Universitaire du Cancer-Oncopole, Toulouse, France.; Université Toulouse III-Paul Sabatier, France., Meindl-Beinker N; Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany., Ruiz-Pace F; Oncology Data Science (ODysSey) Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Élez E; Medical Oncology Department, Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, Spain., Comas-Navarro R; Medical Oncology Department, Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, Spain., Lincoln F; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland., Fey D; Systems Biology Ireland, School of Medicine, University College Dublin, Ireland., Nyamundanda G; Division of Cancer Biology, The Institute of Cancer Research, London, UK., Nolan A; Systems Biology Ireland, School of Medicine, University College Dublin, Ireland., Lewin J; Epigenomics AG, Berlin, Germany., Perez-Lopez R; Radiomics Group, Vall d'Hebron Institute of Oncology (VHIO), Spain., Briody J; Data Science Centre, School of Population Health, RCSI University of Medicine and Health Sciences, Dublin, Ireland., Bennett K; Data Science Centre, School of Population Health, RCSI University of Medicine and Health Sciences, Dublin, Ireland., Kolch W; Systems Biology Ireland, School of Medicine, University College Dublin, Ireland.; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Ireland., Matallanas D; Systems Biology Ireland, School of Medicine, University College Dublin, Ireland., Kel A; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.; geneXplain GmbH, Wolfenbüttel, Germany., Arenas E; Preclinical Research Program, Vall d'Hebron Institute of Oncology (VHIO), Spain., Arribas J; Preclinical Research Program, Vall d'Hebron Institute of Oncology (VHIO), Spain., Ghesquière B; Metabolomics Expertise Center, Leuven, Belgium., Tabernero J; Medical Oncology Department, Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, Spain.; Gastrointestinal and Endocrine Tumor Unit, Vall d'Hebron Institute of Oncology (VHIO), Spain., Meilleroux J; Department of Pathology, Institut Universitaire du Cancer-Oncopole, Toulouse, France.; Université Toulouse III-Paul Sabatier, France., McNamara D; Department of Colorectal Surgery, Beaumont Hospital, Dublin, Ireland.; Department of Surgery, Royal College of Surgeons in Ireland, Dublin, Ireland., McDermott R; Cancer Trials Ireland, Dublin, Ireland.; Department of Medical Oncology, Tallaght University Hospital, Dublin, Ireland.; Department of Medical Oncology, St. Vincent's University Hospital, Dublin, Ireland., Lim M; Department of Medical Oncology, Tallaght University Hospital, Dublin, Ireland., O'Reilly M; Department of Medical Oncology, St. Vincent's University Hospital, Dublin, Ireland., Bird B; Bon Secours Cork Cancer Centre, Bon Secours Hospital Cork, Ireland., Stack L; Bon Secours Cork Cancer Centre, Bon Secours Hospital Cork, Ireland., Moloney L; Bon Secours Cork Cancer Centre, Bon Secours Hospital Cork, Ireland., Morris P; Beaumont RCSI Cancer Centre, Beaumont Hospital, Dublin, Ireland., Egan K; Cancer Clinical Trials and Research Unit, Beaumont RCSI Cancer Centre, Dublin, Ireland., Milewski M; Cancer Clinical Trials and Research Unit, Beaumont RCSI Cancer Centre, Dublin, Ireland., Scheuer L; Onkologische Schwerpunktpraxis Speyer, Germany., Behringer J; Onkologische Schwerpunktpraxis Speyer, Germany., Bolz G; Onkologische Schwerpunktpraxis Speyer, Germany., Salazar R; Medical Oncology Department, Institut Català d'Oncologia, Spain.; Oncobell Program (IDIBELL), Universitat de Barcelona (Campus Bellvitge), Spain., Santos C; Medical Oncology Department, Institut Català d'Oncologia, Spain.; Oncobell Program (IDIBELL), Universitat de Barcelona (Campus Bellvitge), Spain., Ruiz A; Medical Oncology Department, Institut Català d'Oncologia, Spain.; Oncobell Program (IDIBELL), Universitat de Barcelona (Campus Bellvitge), Spain., Casey O; Cancer Trials Ireland, Dublin, Ireland., Murphy V; Cancer Trials Ireland, Dublin, Ireland., Ebert M; Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.; DKFZ-Hector Cancer Institute at the University Medical Center, Mannheim, Germany.; Molecular Medicine Partnership Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Trusolino L; Candiolo Cancer Institute, FPO IRCCS, Torino, Italy.; Department of Oncology, University of Torino, Italy., Lambrechts D; VIB Centre for Cancer Biology, Leuven, Belgium.; Laboratory for Translational Genetics, Department of Human Genetics, Leuven, Belgium., Sadanandam A; Division of Cancer Biology, The Institute of Cancer Research, London, UK., Sautès-Fridman C; Centre de Recherche des Cordeliers, INSERM 1138, Sorbonne Université, Université Paris Cité, France., Prehn J; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland., Nuciforo P; Molecular Oncology Group, Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Barcelona, Spain., Fieschi J; Veracyte SAS, Marseille, France., Monville F; Veracyte SAS, Marseille, France., O'Connor D; School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland., Fridman W; Centre de Recherche des Cordeliers, INSERM 1138, Sorbonne Université, Université Paris Cité, France., Byrne A; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Source: Molecular oncology [Mol Oncol] 2026 Jul; Vol. 20 (7), pp. 1713-1725. Date of Electronic Publication: 2026 Feb 24.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101308230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0261 (Electronic) Linking ISSN: 15747891 NLM ISO Abbreviation: Mol Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1878-0261
DOI:10.1002/1878-0261.70225