A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients.

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Title: A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients.
Authors: Refardt J; Departments of Endocrinology, Diabetology, and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Potasso L; Departments of Endocrinology, Diabetology, and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.; University Institute of Internal Medicine, Cantonal Hospital Baselland, Liestal, Switzerland., Pelouto A; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Trappe M; Emergency Department, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Gregoriano C; Division of Endocrinology, Diabetes, and Metabolism and Division of General Internal Medicine, Medical University Clinic, Medical Faculty, University of Basel, Cantonal Hospital Aarau, Aarau, Switzerland., Koster M; Department of Endocrinology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland., Vodanovic ID; Department of Endocrinology, University Hospital Centre Zagreb, Zagreb, Croatia., Norello D; Pituitary Diseases and Sodium Alterations Unit, Department of Endocrinology, Careggi University Hospital, Florence, Italy., Ravioli S; Department of Internal and Emergency Medicine, Public Hospital Solothurn, Solothurn, Switzerland.; Department of Emergency Medicine, Kepler University Hospital, Johannes Kepler University, Linz, Austria., Cukoski S; Emergency Department, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Boesing M; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.; University Institute of Internal Medicine, Cantonal Hospital Baselland, Liestal, Switzerland., Ryser B; Department of Internal and Emergency Medicine, Public Hospital Solothurn, Solothurn, Switzerland., Sambula L; Department of Endocrinology, University Hospital Centre Zagreb, Zagreb, Croatia., Rapsch N; Emergency Department, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Monnerat S; Departments of Endocrinology, Diabetology, and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland., Beck J; Departments of Endocrinology, Diabetology, and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland., Lustenberger S; Departments of Endocrinology, Diabetology, and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland., Vogt DR; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland., Werlen L; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland., de Jesus JS; Departments of Endocrinology, Diabetology, and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland., Bontognali M; Department of Endocrinology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland., Schuetz P; Division of Endocrinology, Diabetes, and Metabolism and Division of General Internal Medicine, Medical University Clinic, Medical Faculty, University of Basel, Cantonal Hospital Aarau, Aarau, Switzerland., Zandbergen AAM; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Peri A; Pituitary Diseases and Sodium Alterations Unit, Department of Endocrinology, Careggi University Hospital, Florence, Italy.; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy., Kastelan D; Department of Endocrinology, University Hospital Centre Zagreb, Zagreb, Croatia., Lindner G; Department of Internal and Emergency Medicine, Public Hospital Solothurn, Solothurn, Switzerland.; Department of Emergency Medicine, Kepler University Hospital, Johannes Kepler University, Linz, Austria., Leuppi J; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.; University Institute of Internal Medicine, Cantonal Hospital Baselland, Liestal, Switzerland., Bilz S; Department of Endocrinology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland., Mueller B; Division of Endocrinology, Diabetes, and Metabolism and Division of General Internal Medicine, Medical University Clinic, Medical Faculty, University of Basel, Cantonal Hospital Aarau, Aarau, Switzerland., Burst V; Emergency Department, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Hoorn EJ; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Christ-Crain M; Departments of Endocrinology, Diabetology, and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Source: NEJM evidence [NEJM Evid] 2026 Mar; Vol. 5 (3), pp. EVIDoa2500086. Date of Electronic Publication: 2026 Feb 24.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: NEJM Group, a division of the Massachusetts Medical Society Country of Publication: United States NLM ID: 9918317485806676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2766-5526 (Electronic) Linking ISSN: 27665526 NLM ISO Abbreviation: NEJM Evid Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2766-5526
DOI:10.1056/EVIDoa2500086