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Lack of PCK1 in hepatic stellate cells causes liver fibrosis by fueling tricarboxylic acid cycle and increasing glycolysis.

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Title: Lack of PCK1 in hepatic stellate cells causes liver fibrosis by fueling tricarboxylic acid cycle and increasing glycolysis.
Authors: Novoa E; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), 15782 Santiago de Compostela, Spain., Parracho T; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain., Inderhees J; University of Lübeck, Bioanalytic Core Facility, Center for Brain Behaviour and Metabolism, 23562 Lübeck, Germany; University of Lübeck, Institute for Experimental and Clinical Pharmacology and Toxicology, 23562 Lübeck, Germany., Rodriguez A; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), 15782 Santiago de Compostela, Spain; Metabolic Research Laboratory, Clínica Universidad de Navarra and IdiSNA, Pamplona, Spain., Riobello C; Department of Biochemistry and Molecular Biology, CIMUS, IDIS, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain., Iglesias-Moure J; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain., Fernández-Iglesias A; Liver Vascular Biology Lab, IDIBAPS - Hospital Clínic de Barcelona - CIBEREHD, 08036 Barcelona, Spain., Martinez-Martinez S; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain., Senra A; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain., Seoane S; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain., Fondevila M; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), 15782 Santiago de Compostela, Spain., Iglesias C; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain., Cabaleiro A; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain., da Silva Lima N; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain., Dorta V; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain., López-Picallo B; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain., Ramos-Lage L; Department of Biochemistry and Molecular Biology, CIMUS, IDIS, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain., Woodhoo A; Department of Biochemistry and Molecular Biology, CIMUS, IDIS, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain., Fidalgo M; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain., Martínez-Chantar ML; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, 48160 Bizkaia, Spain; CIBER Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, 28029 Madrid, Spain., Cubero FJ; Department of Immunology, Ophthalmology & ENT, Complutense University School of Medicine, 28040 Madrid, Spain; Institute for Research in Neurochemistry (IUIN), Complutense University of Madrid, Madrid, Spain; Health Research Institute Gregorio Marañón (IiSGM), 28007 Madrid, Spain; CIBER Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, 28029 Madrid, Spain., López M; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), 15782 Santiago de Compostela, Spain., Dieguez C; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), 15782 Santiago de Compostela, Spain., Guallar D; Department of Biochemistry and Molecular Biology, CIMUS, IDIS, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain., Prevot V; Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, European Genomic Institute for Diabetes (EGID), 59000 Lille, France., Schwabe RF; Department of Medicine, Columbia University, New York, NY 10027, USA., Frühbeck G; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), 15782 Santiago de Compostela, Spain; Metabolic Research Laboratory, Clínica Universidad de Navarra and IdiSNA, Pamplona, Spain., Crespo J; Gastroenterology and Hepatology Department, Marqués de Valdecilla University Hospital, Clinical and Translational Digestive Research Group, IDIVAL, 39008 Santander, Spain., Varela-Rey M; Department of Biochemistry and Molecular Biology, CIMUS, IDIS, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain., Gonzalez-Rellan MJ; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain., Gracia-Sancho J; Liver Vascular Biology Lab, IDIBAPS - Hospital Clínic de Barcelona - CIBEREHD, 08036 Barcelona, Spain., Iruzubieta P; Department of Medicine, Columbia University, New York, NY 10027, USA., Schwaninger M; University of Lübeck, Bioanalytic Core Facility, Center for Brain Behaviour and Metabolism, 23562 Lübeck, Germany., Nogueiras R; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), 15782 Santiago de Compostela, Spain; Galicia Agency of Innovation (GAIN), Xunta de Galicia, 15702 Santiago de Compostela, Spain. Electronic address: ruben.nogueiras@usc.es.
Source: Cell metabolism [Cell Metab] 2026 Apr 07; Vol. 38 (4), pp. 729-745.e9. Date of Electronic Publication: 2026 Feb 23.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-7420 (Electronic) Linking ISSN: 15504131 NLM ISO Abbreviation: Cell Metab Subsets: MEDLINE
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  Data: Lack of PCK1 in hepatic stellate cells causes liver fibrosis by fueling tricarboxylic acid cycle and increasing glycolysis.
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  Data: <searchLink fieldCode="AU" term="%22Novoa+E%22">Novoa E</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Parracho+T%22">Parracho T</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Inderhees+J%22">Inderhees J</searchLink>; University of Lübeck, Bioanalytic Core Facility, Center for Brain Behaviour and Metabolism, 23562 Lübeck, Germany; University of Lübeck, Institute for Experimental and Clinical Pharmacology and Toxicology, 23562 Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Rodriguez+A%22">Rodriguez A</searchLink>; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), 15782 Santiago de Compostela, Spain; Metabolic Research Laboratory, Clínica Universidad de Navarra and IdiSNA, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Riobello+C%22">Riobello C</searchLink>; Department of Biochemistry and Molecular Biology, CIMUS, IDIS, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Iglesias-Moure+J%22">Iglesias-Moure J</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Fernández-Iglesias+A%22">Fernández-Iglesias A</searchLink>; Liver Vascular Biology Lab, IDIBAPS - Hospital Clínic de Barcelona - CIBEREHD, 08036 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Martinez-Martinez+S%22">Martinez-Martinez S</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Senra+A%22">Senra A</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Seoane+S%22">Seoane S</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Fondevila+M%22">Fondevila M</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Iglesias+C%22">Iglesias C</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Cabaleiro+A%22">Cabaleiro A</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22da+Silva+Lima+N%22">da Silva Lima N</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Dorta+V%22">Dorta V</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22López-Picallo+B%22">López-Picallo B</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Ramos-Lage+L%22">Ramos-Lage L</searchLink>; Department of Biochemistry and Molecular Biology, CIMUS, IDIS, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Woodhoo+A%22">Woodhoo A</searchLink>; Department of Biochemistry and Molecular Biology, CIMUS, IDIS, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Fidalgo+M%22">Fidalgo M</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Martínez-Chantar+ML%22">Martínez-Chantar ML</searchLink>; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, 48160 Bizkaia, Spain; CIBER Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, 28029 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Cubero+FJ%22">Cubero FJ</searchLink>; Department of Immunology, Ophthalmology & ENT, Complutense University School of Medicine, 28040 Madrid, Spain; Institute for Research in Neurochemistry (IUIN), Complutense University of Madrid, Madrid, Spain; Health Research Institute Gregorio Marañón (IiSGM), 28007 Madrid, Spain; CIBER Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, 28029 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22López+M%22">López M</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Dieguez+C%22">Dieguez C</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Guallar+D%22">Guallar D</searchLink>; Department of Biochemistry and Molecular Biology, CIMUS, IDIS, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Prevot+V%22">Prevot V</searchLink>; Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, European Genomic Institute for Diabetes (EGID), 59000 Lille, France.<br /><searchLink fieldCode="AU" term="%22Schwabe+RF%22">Schwabe RF</searchLink>; Department of Medicine, Columbia University, New York, NY 10027, USA.<br /><searchLink fieldCode="AU" term="%22Frühbeck+G%22">Frühbeck G</searchLink>; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), 15782 Santiago de Compostela, Spain; Metabolic Research Laboratory, Clínica Universidad de Navarra and IdiSNA, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Crespo+J%22">Crespo J</searchLink>; Gastroenterology and Hepatology Department, Marqués de Valdecilla University Hospital, Clinical and Translational Digestive Research Group, IDIVAL, 39008 Santander, Spain.<br /><searchLink fieldCode="AU" term="%22Varela-Rey+M%22">Varela-Rey M</searchLink>; Department of Biochemistry and Molecular Biology, CIMUS, IDIS, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Rellan+MJ%22">Gonzalez-Rellan MJ</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Gracia-Sancho+J%22">Gracia-Sancho J</searchLink>; Liver Vascular Biology Lab, IDIBAPS - Hospital Clínic de Barcelona - CIBEREHD, 08036 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Iruzubieta+P%22">Iruzubieta P</searchLink>; Department of Medicine, Columbia University, New York, NY 10027, USA.<br /><searchLink fieldCode="AU" term="%22Schwaninger+M%22">Schwaninger M</searchLink>; University of Lübeck, Bioanalytic Core Facility, Center for Brain Behaviour and Metabolism, 23562 Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Nogueiras+R%22">Nogueiras R</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), 15782 Santiago de Compostela, Spain; Galicia Agency of Innovation (GAIN), Xunta de Galicia, 15702 Santiago de Compostela, Spain. Electronic address: ruben.nogueiras@usc.es.
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