Impact of mobilization dose on outcome of critically ill patients receiving mechanical ventilation-a target trial emulation using data from the TEAM trial.

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Title: Impact of mobilization dose on outcome of critically ill patients receiving mechanical ventilation-a target trial emulation using data from the TEAM trial.
Authors: Serpa Neto A; Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Intensive Care, Austin Hospital, Heidelberg, Australia.; Department of Critical Care, University of Melbourne, Melbourne, VIC, Australia.; Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil., Bailey M; Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia., Seller D; Medical Research Institute of New Zealand, Wellington, New Zealand.; Physiotherapy Team, Te Whatu Ora-Capital, Coast, Wellington, New Zealand.; School of Physiotherapy, University of Otago, Wellington, New Zealand., Agli A; Intensive Care Unit, Princess Alexandra Hospital, Queensland, Australia., Bellomo R; Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Intensive Care, Austin Hospital, Heidelberg, Australia.; Department of Critical Care, University of Melbourne, Melbourne, VIC, Australia.; Department of Intensive Care, Royal Melbourne Hospital, Melbourne, VIC, Australia., Brickell K; University College Dublin-Clinical Research Centre at St Vincent's University Hospital, Dublin, Ireland., Broadley T; Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia., Buhr H; Intensive Care Services, Royal Prince Alfred Hospital, Sydney, NSW, Australia., Gabbe BJ; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia., Gould DW; Clinical Trials Unit, Intensive Care National Audit and Research Centre, London, United Kingdom., Harrold M; Curtin School of Allied Health, Curtin University, Bentley, WA, Australia.; Department of Physiotherapy, Royal Perth Hospital, Perth, WA, Australia., Higgins AM; Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia., Hurford S; Medical Research Institute of New Zealand, Wellington, New Zealand., Iwashyna TJ; Department of Internal Medicine Division of Pulmonary and Critical Care, University of Michigan, Ann Arbor, MI, United States.; Department of Medicine Division of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, MD, United States., Nichol AD; Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; University College Dublin-Clinical Research Centre at St Vincent's University Hospital, Dublin, Ireland.; Department of Intensive Care, Alfred Hospital, Melbourne, VIC, Australia., Presneill JJ; Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Critical Care, University of Melbourne, Melbourne, VIC, Australia.; Department of Intensive Care, Royal Melbourne Hospital, Melbourne, VIC, Australia.; School of Medicine, University of Melbourne, Melbourne, VIC, Australia., Schaller SJ; Department of Anesthesiology and Intensive Care, School of Medicine, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany.; Department of Anesthesiology and Intensive Care Medicine, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Sivasuthan J; Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia., Tipping CJ; Intensive Care Unit and Physiotherapy Department, The Alfred Hospital, Melbourne, VIC, Australia., Webb S; Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Intensive Care Unit, St John of God Hospital Subiaco, Perth, WA, Australia., Young PJ; Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Critical Care, University of Melbourne, Melbourne, VIC, Australia.; Medical Research Institute of New Zealand, Wellington, New Zealand.; Intensive Care Unit, Wellington Hospital, Wellington, New Zealand., Hodgson CL; Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Critical Care, University of Melbourne, Melbourne, VIC, Australia.; Intensive Care Unit and Physiotherapy Department, The Alfred Hospital, Melbourne, VIC, Australia.
Corporate Authors: TEAM Study Investigators and the ANZICS Clinical Trials Group
Source: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2026 Mar 01; Vol. 212 (3), pp. 500-510.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: American Thoracic Society Country of Publication: England NLM ID: 9421642 Publication Model: Print Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Impact of mobilization dose on outcome of critically ill patients receiving mechanical ventilation-a target trial emulation using data from the TEAM trial.
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  Data: <searchLink fieldCode="AU" term="%22Serpa+Neto+A%22">Serpa Neto A</searchLink>; Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Intensive Care, Austin Hospital, Heidelberg, Australia.; Department of Critical Care, University of Melbourne, Melbourne, VIC, Australia.; Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Bailey+M%22">Bailey M</searchLink>; Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Seller+D%22">Seller D</searchLink>; Medical Research Institute of New Zealand, Wellington, New Zealand.; Physiotherapy Team, Te Whatu Ora-Capital, Coast, Wellington, New Zealand.; School of Physiotherapy, University of Otago, Wellington, New Zealand.<br /><searchLink fieldCode="AU" term="%22Agli+A%22">Agli A</searchLink>; Intensive Care Unit, Princess Alexandra Hospital, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Bellomo+R%22">Bellomo R</searchLink>; Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Intensive Care, Austin Hospital, Heidelberg, Australia.; Department of Critical Care, University of Melbourne, Melbourne, VIC, Australia.; Department of Intensive Care, Royal Melbourne Hospital, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Brickell+K%22">Brickell K</searchLink>; University College Dublin-Clinical Research Centre at St Vincent's University Hospital, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Broadley+T%22">Broadley T</searchLink>; Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Buhr+H%22">Buhr H</searchLink>; Intensive Care Services, Royal Prince Alfred Hospital, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Gabbe+BJ%22">Gabbe BJ</searchLink>; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Gould+DW%22">Gould DW</searchLink>; Clinical Trials Unit, Intensive Care National Audit and Research Centre, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Harrold+M%22">Harrold M</searchLink>; Curtin School of Allied Health, Curtin University, Bentley, WA, Australia.; Department of Physiotherapy, Royal Perth Hospital, Perth, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Higgins+AM%22">Higgins AM</searchLink>; Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Hurford+S%22">Hurford S</searchLink>; Medical Research Institute of New Zealand, Wellington, New Zealand.<br /><searchLink fieldCode="AU" term="%22Iwashyna+TJ%22">Iwashyna TJ</searchLink>; Department of Internal Medicine Division of Pulmonary and Critical Care, University of Michigan, Ann Arbor, MI, United States.; Department of Medicine Division of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22Nichol+AD%22">Nichol AD</searchLink>; Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; University College Dublin-Clinical Research Centre at St Vincent's University Hospital, Dublin, Ireland.; Department of Intensive Care, Alfred Hospital, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Presneill+JJ%22">Presneill JJ</searchLink>; Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Critical Care, University of Melbourne, Melbourne, VIC, Australia.; Department of Intensive Care, Royal Melbourne Hospital, Melbourne, VIC, Australia.; School of Medicine, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Schaller+SJ%22">Schaller SJ</searchLink>; Department of Anesthesiology and Intensive Care, School of Medicine, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany.; Department of Anesthesiology and Intensive Care Medicine, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Sivasuthan+J%22">Sivasuthan J</searchLink>; Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Tipping+CJ%22">Tipping CJ</searchLink>; Intensive Care Unit and Physiotherapy Department, The Alfred Hospital, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Webb+S%22">Webb S</searchLink>; Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Intensive Care Unit, St John of God Hospital Subiaco, Perth, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Young+PJ%22">Young PJ</searchLink>; Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Critical Care, University of Melbourne, Melbourne, VIC, Australia.; Medical Research Institute of New Zealand, Wellington, New Zealand.; Intensive Care Unit, Wellington Hospital, Wellington, New Zealand.<br /><searchLink fieldCode="AU" term="%22Hodgson+CL%22">Hodgson CL</searchLink>; Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Critical Care, University of Melbourne, Melbourne, VIC, Australia.; Intensive Care Unit and Physiotherapy Department, The Alfred Hospital, Melbourne, VIC, Australia.
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