Lower airway immunophenotyping in severe preschool wheeze reveals distinct clusters described by heterogeneity in neutrophil phenotypes.

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Title: Lower airway immunophenotyping in severe preschool wheeze reveals distinct clusters described by heterogeneity in neutrophil phenotypes.
Authors: Bonner KL; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Fontanella S; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Centre for Paediatrics and Child Health, Imperial College London, London, United Kingdom., Gore M; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Centre for Paediatrics and Child Health, Imperial College London, London, United Kingdom., Cook J; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Hoffland A; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Scotney E; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Centre for Paediatrics and Child Health, Imperial College London, London, United Kingdom., Tian K; Immunoregulation and Infection Laboratory, Francis Crick Institute, London, United Kingdom., Hillson K; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Shamji M; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Layhadi J; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Al-Kuwari H; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Bush A; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Centre for Paediatrics and Child Health, Imperial College London, London, United Kingdom.; Department of Respiratory Paediatrics, Royal Brompton Hospital, London, United Kingdom., Custovic A; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Centre for Paediatrics and Child Health, Imperial College London, London, United Kingdom., Lloyd CM; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Saglani S; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Centre for Paediatrics and Child Health, Imperial College London, London, United Kingdom.; Department of Respiratory Paediatrics, Royal Brompton Hospital, London, United Kingdom.
Corporate Authors: Breathing Together Investigators
Source: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2026 Apr 01; Vol. 212 (4), pp. 733-745.
Publication Type: Journal Article
Journal Info: Publisher: American Thoracic Society Country of Publication: England NLM ID: 9421642 Publication Model: Print Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:1535-4970
DOI:10.1093/ajrccm/aamaf119