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Lower airway immunophenotyping in severe preschool wheeze reveals distinct clusters described by heterogeneity in neutrophil phenotypes.

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Title: Lower airway immunophenotyping in severe preschool wheeze reveals distinct clusters described by heterogeneity in neutrophil phenotypes.
Authors: Bonner KL; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Fontanella S; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Centre for Paediatrics and Child Health, Imperial College London, London, United Kingdom., Gore M; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Centre for Paediatrics and Child Health, Imperial College London, London, United Kingdom., Cook J; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Hoffland A; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Scotney E; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Centre for Paediatrics and Child Health, Imperial College London, London, United Kingdom., Tian K; Immunoregulation and Infection Laboratory, Francis Crick Institute, London, United Kingdom., Hillson K; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Shamji M; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Layhadi J; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Al-Kuwari H; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Bush A; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Centre for Paediatrics and Child Health, Imperial College London, London, United Kingdom.; Department of Respiratory Paediatrics, Royal Brompton Hospital, London, United Kingdom., Custovic A; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Centre for Paediatrics and Child Health, Imperial College London, London, United Kingdom., Lloyd CM; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Saglani S; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Centre for Paediatrics and Child Health, Imperial College London, London, United Kingdom.; Department of Respiratory Paediatrics, Royal Brompton Hospital, London, United Kingdom.
Corporate Authors: Breathing Together Investigators
Source: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2026 Apr 01; Vol. 212 (4), pp. 733-745.
Publication Type: Journal Article
Journal Info: Publisher: American Thoracic Society Country of Publication: England NLM ID: 9421642 Publication Model: Print Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Lower airway immunophenotyping in severe preschool wheeze reveals distinct clusters described by heterogeneity in neutrophil phenotypes.
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  Data: <searchLink fieldCode="AU" term="%22Bonner+KL%22">Bonner KL</searchLink>; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Fontanella+S%22">Fontanella S</searchLink>; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Centre for Paediatrics and Child Health, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gore+M%22">Gore M</searchLink>; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Centre for Paediatrics and Child Health, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Cook+J%22">Cook J</searchLink>; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hoffland+A%22">Hoffland A</searchLink>; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Scotney+E%22">Scotney E</searchLink>; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Centre for Paediatrics and Child Health, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tian+K%22">Tian K</searchLink>; Immunoregulation and Infection Laboratory, Francis Crick Institute, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hillson+K%22">Hillson K</searchLink>; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Shamji+M%22">Shamji M</searchLink>; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Layhadi+J%22">Layhadi J</searchLink>; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Al-Kuwari+H%22">Al-Kuwari H</searchLink>; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bush+A%22">Bush A</searchLink>; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Centre for Paediatrics and Child Health, Imperial College London, London, United Kingdom.; Department of Respiratory Paediatrics, Royal Brompton Hospital, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Custovic+A%22">Custovic A</searchLink>; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Centre for Paediatrics and Child Health, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lloyd+CM%22">Lloyd CM</searchLink>; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Saglani+S%22">Saglani S</searchLink>; Inflammation Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Centre for Paediatrics and Child Health, Imperial College London, London, United Kingdom.; Department of Respiratory Paediatrics, Royal Brompton Hospital, London, United Kingdom.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Thoracic+Society%22">American Thoracic Society </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9421642 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1535-4970 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221073449X%22">1073449X </searchLink><i>NLM ISO Abbreviation: </i>Am J Respir Crit Care Med <i>Subsets: </i>MEDLINE
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              Text: 2026 Apr 01
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