Spatial transcriptomics uncovers hybrid, proinflammatory, and profibrotic cellular niches in pulmonary granuloma of patients with chronic sarcoidosis.
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| Title: | Spatial transcriptomics uncovers hybrid, proinflammatory, and profibrotic cellular niches in pulmonary granuloma of patients with chronic sarcoidosis. |
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| Authors: | Christian L; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany., Yilmaz H; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany., Ruwisch J; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany., Giercke L; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany., Seeliger B; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany., Kamp JC; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany., Bayraktar S; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany., Ewen R; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany., Graalmann T; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.; Junior Research Group Translational Immunology, TWINCORE, Center for Experimental and Clinical Infection Research, a Joint Venture between the Helmholtz Center for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany.; Department for Rheumatology and Immunology, Hannover Medical School (MHH), Hannover, Germany., Fuge J; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany., Greer M; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany., Ius F; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.; Clinic for Cardiac, Thoracic, Transplant and Vascular Surgery, Hannover Medical School (MHH), Hannover, Germany., Welte T; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany., Liao SY; Department of Medicine, National Jewish Health, Denver, CO, United States., Yang IV; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, United States., Hohlfeld JM; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.; Division of Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany., Hoeper MM; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany., Gottlieb J; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany., Kaminski N; Pulmonary, Critical Care and Sleep Medicine, Yale University, New Haven, CT, United States., Prasse A; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.; Division of Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany.; Clinics of Respiratory Medicine, University Hospital Basel, University of Basel, Basel, Switzerland., Jonigk D; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.; Institute of Pathology, Hannover Medical School (MHH), Hannover, Germany.; University Clinic of the RWTH Aachen, Aachen, Germany., Li Y; Computational Biology for Individualised Medicine, TWINCORE, Center for Experimental and Clinical Infection Research, a Joint Venture between the Helmholtz Center for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany.; Department of Computational Biology for Individualised Medicine, Center for Individualised Infection Medicine (CiiM), a Joint Venture between the Helmholtz Center for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany.; Lower Saxony Center for Artificial Intelligence and Causal Methods in Medicine (CAIMed), Hannover, Germany.; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.; Cluster of Excellence Resolving Infection Susceptibility (RESIST), Hannover, Germany., Falk C; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.; Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany., Neubert L; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.; Institute of Pathology, Hannover Medical School (MHH), Hannover, Germany., Schupp JC; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.; Division of Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany.; Pulmonary, Critical Care and Sleep Medicine, Yale University, New Haven, CT, United States. |
| Source: | American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2026 Feb 01; Vol. 212 (2), pp. 338-350. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Thoracic Society Country of Publication: England NLM ID: 9421642 Publication Model: Print Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1535-4970 |
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| DOI: | 10.1093/ajrccm/aamaf089 |
