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Hydrophobic Refinement of Polarity-Switchable Lipo-Xenopeptides Modulates Endosomal Escape and Enhances mRNA Delivery In Vitro and In Vivo.

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Title: Hydrophobic Refinement of Polarity-Switchable Lipo-Xenopeptides Modulates Endosomal Escape and Enhances mRNA Delivery In Vitro and In Vivo.
Authors: Burghardt T; Pharmaceutical Biotechnology, Department of Pharmacy, LMU Munich, 81377 Munich, Germany., Thalmayr S; Pharmaceutical Biotechnology, Department of Pharmacy, LMU Munich, 81377 Munich, Germany.; Center for NanoScience (CeNS), LMU Munich, 80799 Munich, Germany., Obeser L; Pharmaceutical Chemistry, Department of Pharmacy, LMU Munich, 81377 Munich, Germany., Pöhmerer J; Pharmaceutical Biotechnology, Department of Pharmacy, LMU Munich, 81377 Munich, Germany., Yazdi M; Pharmaceutical Biotechnology, Department of Pharmacy, LMU Munich, 81377 Munich, Germany., Höhn M; Pharmaceutical Biotechnology, Department of Pharmacy, LMU Munich, 81377 Munich, Germany., Völkl M; Pharmaceutical Biology, Department of Pharmacy, LMU Munich, 81377 Munich, Germany., Sieber-Schäfer F; Pharmaceutical Technology and Biopharmaceutics, Department of Pharmacy, LMU Munich, 81377 Munich, Germany., Zahler S; Pharmaceutical Biology, Department of Pharmacy, LMU Munich, 81377 Munich, Germany., Merkel OM; Center for NanoScience (CeNS), LMU Munich, 80799 Munich, Germany.; Pharmaceutical Technology and Biopharmaceutics, Department of Pharmacy, LMU Munich, 81377 Munich, Germany., Merk D; Pharmaceutical Chemistry, Department of Pharmacy, LMU Munich, 81377 Munich, Germany., Wagner E; Pharmaceutical Biotechnology, Department of Pharmacy, LMU Munich, 81377 Munich, Germany.; Center for NanoScience (CeNS), LMU Munich, 80799 Munich, Germany.
Source: Journal of the American Chemical Society [J Am Chem Soc] 2026 Mar 11; Vol. 148 (9), pp. 9449-9464. Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-5126
DOI:10.1021/jacs.5c19141