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Plasminogen supplementation reverses fibrinolytic insufficiency in sepsis-induced disseminated intravascular coagulation: a pilot study.

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Title: Plasminogen supplementation reverses fibrinolytic insufficiency in sepsis-induced disseminated intravascular coagulation: a pilot study.
Authors: Tschirhart M; INSERM (French National Institute of Health and Medical Research) UMR 1260, Regenerative Nanomedicine (RNM), Strasbourg, France., Curtiaud A; INSERM (French National Institute of Health and Medical Research) UMR 1260, Regenerative Nanomedicine (RNM), Strasbourg, France.; Université de Strasbourg (UNISTRA), Strasbourg, France.; Service de Médecine Intensive-Réanimation, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Fédération Hospitalo-Universitaire TARGET, Strasbourg, France., Abou Rjeily R; Université Paris Cité, INSERM UMR_S 1144, Équipe 4, Optimisation Thérapeutique en Neuropharmacologie, Paris, France., Merdji H; INSERM (French National Institute of Health and Medical Research) UMR 1260, Regenerative Nanomedicine (RNM), Strasbourg, France.; Université de Strasbourg (UNISTRA), Strasbourg, France.; Service de Médecine Intensive-Réanimation, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Fédération Hospitalo-Universitaire TARGET, Strasbourg, France., Demiselle J; INSERM (French National Institute of Health and Medical Research) UMR 1260, Regenerative Nanomedicine (RNM), Strasbourg, France.; Université de Strasbourg (UNISTRA), Strasbourg, France.; Service de Médecine Intensive-Réanimation, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Fédération Hospitalo-Universitaire TARGET, Strasbourg, France., Severac F; Groupe Méthodes en Recherche Clinique (GMRC), Hôpitaux Universitaires de Strasbourg, Strasbourg, France., Guerin D; Université Paris Cité, INSERM UMR_S 1144, Équipe 4, Optimisation Thérapeutique en Neuropharmacologie, Paris, France., Caçao M; Université Paris Cité, INSERM UMR_S 1144, Équipe 4, Optimisation Thérapeutique en Neuropharmacologie, Paris, France., El Ghazouani F; INSERM (French National Institute of Health and Medical Research) UMR 1260, Regenerative Nanomedicine (RNM), Strasbourg, France., Angles-Cano E; Université Paris Cité, INSERM UMR_S 1144, Équipe 4, Optimisation Thérapeutique en Neuropharmacologie, Paris, France., Toti F; INSERM (French National Institute of Health and Medical Research) UMR 1260, Regenerative Nanomedicine (RNM), Strasbourg, France.; Université de Strasbourg (UNISTRA), Strasbourg, France., Meziani F; INSERM (French National Institute of Health and Medical Research) UMR 1260, Regenerative Nanomedicine (RNM), Strasbourg, France.; Université de Strasbourg (UNISTRA), Strasbourg, France.; Service de Médecine Intensive-Réanimation, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Fédération Hospitalo-Universitaire TARGET, Strasbourg, France., Helms J; INSERM (French National Institute of Health and Medical Research) UMR 1260, Regenerative Nanomedicine (RNM), Strasbourg, France. julie.helms@chru-strasbourg.fr.; Université de Strasbourg (UNISTRA), Strasbourg, France. julie.helms@chru-strasbourg.fr.; Service de Médecine Intensive-Réanimation, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Fédération Hospitalo-Universitaire TARGET, Strasbourg, France. julie.helms@chru-strasbourg.fr.
Source: Intensive care medicine [Intensive Care Med] 2026 Mar; Vol. 52 (3), pp. 456-465. Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Springer Verlag Country of Publication: United States NLM ID: 7704851 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1238 (Electronic) Linking ISSN: 03424642 NLM ISO Abbreviation: Intensive Care Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-1238
DOI:10.1007/s00134-026-08338-0