Osteocytic Lipocalin-2 regulates bone formation locally through iron-dependent ferroptosis and Wnt suppression.

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Title: Osteocytic Lipocalin-2 regulates bone formation locally through iron-dependent ferroptosis and Wnt suppression.
Authors: Khanal V; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Carroll M; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Moradi F; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Carter J; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Zhong Y; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Arkansas Children's Nutrition Center, Little Rock, AR, USA., Shashank CG; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Arkansas Children's Nutrition Center, Little Rock, AR, USA., Sato AY; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Allen RM; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Wankhade UD; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Arkansas Children's Nutrition Center, Little Rock, AR, USA., Dole NS; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. NSDole@uams.edu.; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA. NSDole@uams.edu.; Arkansas Children's Nutrition Center, Little Rock, AR, USA. NSDole@uams.edu.; Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA. NSDole@uams.edu.
Source: Cell death discovery [Cell Death Discov] 2026 Feb 25; Vol. 12 (1). Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:2058-7716
DOI:10.1038/s41420-026-02956-9