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Osteocytic Lipocalin-2 regulates bone formation locally through iron-dependent ferroptosis and Wnt suppression.

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Title: Osteocytic Lipocalin-2 regulates bone formation locally through iron-dependent ferroptosis and Wnt suppression.
Authors: Khanal V; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Carroll M; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Moradi F; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Carter J; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Zhong Y; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Arkansas Children's Nutrition Center, Little Rock, AR, USA., Shashank CG; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Arkansas Children's Nutrition Center, Little Rock, AR, USA., Sato AY; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Allen RM; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Wankhade UD; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Arkansas Children's Nutrition Center, Little Rock, AR, USA., Dole NS; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. NSDole@uams.edu.; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA. NSDole@uams.edu.; Arkansas Children's Nutrition Center, Little Rock, AR, USA. NSDole@uams.edu.; Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA. NSDole@uams.edu.
Source: Cell death discovery [Cell Death Discov] 2026 Feb 25; Vol. 12 (1). Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Osteocytic Lipocalin-2 regulates bone formation locally through iron-dependent ferroptosis and Wnt suppression.
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  Data: <searchLink fieldCode="AU" term="%22Khanal+V%22">Khanal V</searchLink>; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.<br /><searchLink fieldCode="AU" term="%22Carroll+M%22">Carroll M</searchLink>; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.<br /><searchLink fieldCode="AU" term="%22Moradi+F%22">Moradi F</searchLink>; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.<br /><searchLink fieldCode="AU" term="%22Carter+J%22">Carter J</searchLink>; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.<br /><searchLink fieldCode="AU" term="%22Zhong+Y%22">Zhong Y</searchLink>; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Arkansas Children's Nutrition Center, Little Rock, AR, USA.<br /><searchLink fieldCode="AU" term="%22Shashank+CG%22">Shashank CG</searchLink>; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Arkansas Children's Nutrition Center, Little Rock, AR, USA.<br /><searchLink fieldCode="AU" term="%22Sato+AY%22">Sato AY</searchLink>; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.<br /><searchLink fieldCode="AU" term="%22Allen+RM%22">Allen RM</searchLink>; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.<br /><searchLink fieldCode="AU" term="%22Wankhade+UD%22">Wankhade UD</searchLink>; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Arkansas Children's Nutrition Center, Little Rock, AR, USA.<br /><searchLink fieldCode="AU" term="%22Dole+NS%22">Dole NS</searchLink>; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. NSDole@uams.edu.; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA. NSDole@uams.edu.; Arkansas Children's Nutrition Center, Little Rock, AR, USA. NSDole@uams.edu.; Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA. NSDole@uams.edu.
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  Data: <searchLink fieldCode="JN" term="%22101665035%22">Cell death discovery</searchLink> [Cell Death Discov] 2026 Feb 25; Vol. 12 (1). <i>Date of Electronic Publication: </i>2026 Feb 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101665035 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2058-7716 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220587716%22">20587716 </searchLink><i>NLM ISO Abbreviation: </i>Cell Death Discov <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41741421
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        Value: 10.1038/s41420-026-02956-9
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        Text: English
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      – TitleFull: Osteocytic Lipocalin-2 regulates bone formation locally through iron-dependent ferroptosis and Wnt suppression.
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              Text: 2026 Feb 25
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              Y: 2026
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