Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis.

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Title: Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis.
Authors: Fiskin E; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Eraslan G; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Alora-Palli MB; Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Jain T; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Leyva-Castillo JM; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Kim S; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Choe H; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Lareau CA; Departments of Pathology, Stanford University, Stanford, CA, USA.; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Lau H; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Finan EP; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Teixeira-Soldano I; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., LaBere B; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Division of Pulmonology, Section of Allergy-Immunology, Phoenix Children's Hospital, Phoenix, AZ, USA., Chu A; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Woods B; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Chou J; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Slyper M; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Waldman J; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Islam S; Division of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Schneider L; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Phipatanakul W; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Platt C; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Rozenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Delorey TM; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Ashenberg O; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Deguine J; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Smith GP; Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Geha RS; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. raif.geha@childrens.harvard.edu., Regev A; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA. aviv.regev.sc@gmail.com.; Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA. aviv.regev.sc@gmail.com.; Genentech, South San Francisco, CA, USA. aviv.regev.sc@gmail.com., Xavier RJ; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA. xavier@molbio.mgh.harvard.edu.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. xavier@molbio.mgh.harvard.edu.; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. xavier@molbio.mgh.harvard.edu.
Source: Nature communications [Nat Commun] 2026 Feb 25; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-69587-7