Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis.
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| Title: | Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis. |
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| Authors: | Fiskin E; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Eraslan G; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Alora-Palli MB; Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Jain T; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Leyva-Castillo JM; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Kim S; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Choe H; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Lareau CA; Departments of Pathology, Stanford University, Stanford, CA, USA.; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Lau H; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Finan EP; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Teixeira-Soldano I; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., LaBere B; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Division of Pulmonology, Section of Allergy-Immunology, Phoenix Children's Hospital, Phoenix, AZ, USA., Chu A; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Woods B; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Chou J; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Slyper M; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Waldman J; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Islam S; Division of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Schneider L; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Phipatanakul W; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Platt C; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Rozenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Delorey TM; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Ashenberg O; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Deguine J; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Smith GP; Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Geha RS; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. raif.geha@childrens.harvard.edu., Regev A; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA. aviv.regev.sc@gmail.com.; Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA. aviv.regev.sc@gmail.com.; Genentech, South San Francisco, CA, USA. aviv.regev.sc@gmail.com., Xavier RJ; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA. xavier@molbio.mgh.harvard.edu.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. xavier@molbio.mgh.harvard.edu.; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. xavier@molbio.mgh.harvard.edu. |
| Source: | Nature communications [Nat Commun] 2026 Feb 25; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 25. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41741455 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Fiskin+E%22">Fiskin E</searchLink>; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Eraslan+G%22">Eraslan G</searchLink>; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Alora-Palli+MB%22">Alora-Palli MB</searchLink>; Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jain+T%22">Jain T</searchLink>; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Leyva-Castillo+JM%22">Leyva-Castillo JM</searchLink>; 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Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Delorey+TM%22">Delorey TM</searchLink>; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ashenberg+O%22">Ashenberg O</searchLink>; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Deguine+J%22">Deguine J</searchLink>; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Smith+GP%22">Smith GP</searchLink>; Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Geha+RS%22">Geha RS</searchLink>; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. raif.geha@childrens.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Regev+A%22">Regev A</searchLink>; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA. aviv.regev.sc@gmail.com.; Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA. aviv.regev.sc@gmail.com.; Genentech, South San Francisco, CA, USA. aviv.regev.sc@gmail.com.<br /><searchLink fieldCode="AU" term="%22Xavier+RJ%22">Xavier RJ</searchLink>; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA. xavier@molbio.mgh.harvard.edu.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. xavier@molbio.mgh.harvard.edu.; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. xavier@molbio.mgh.harvard.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Feb 25; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Feb 25. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. 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| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41741455 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41467-026-69587-7 Languages: – Code: eng Text: English Titles: – TitleFull: Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fiskin E – PersonEntity: Name: NameFull: Eraslan G – PersonEntity: Name: NameFull: Alora-Palli MB – PersonEntity: Name: NameFull: Jain T – PersonEntity: Name: NameFull: Leyva-Castillo JM – PersonEntity: Name: NameFull: Kim S – PersonEntity: Name: NameFull: Choe H – PersonEntity: Name: NameFull: Lareau CA – PersonEntity: Name: NameFull: Lau H – PersonEntity: Name: NameFull: Finan EP – PersonEntity: Name: NameFull: Teixeira-Soldano I – PersonEntity: Name: NameFull: LaBere B – PersonEntity: Name: NameFull: Chu A – PersonEntity: Name: NameFull: Woods B – PersonEntity: Name: NameFull: Chou J – PersonEntity: Name: NameFull: Slyper M – PersonEntity: Name: NameFull: Waldman J – PersonEntity: Name: NameFull: Islam S – PersonEntity: Name: NameFull: Schneider L – PersonEntity: Name: NameFull: Phipatanakul W – PersonEntity: Name: NameFull: Platt C – PersonEntity: Name: NameFull: Rozenblatt-Rosen O – PersonEntity: Name: NameFull: Delorey TM – PersonEntity: Name: NameFull: Ashenberg O – PersonEntity: Name: NameFull: Deguine J – PersonEntity: Name: NameFull: Smith GP – PersonEntity: Name: NameFull: Geha RS – PersonEntity: Name: NameFull: Regev A – PersonEntity: Name: NameFull: Xavier RJ IsPartOfRelationships: – BibEntity: Dates: – D: 25 M: 02 Text: 2026 Feb 25 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2041-1723 Numbering: – Type: volume Value: 17 – Type: issue Value: 1 Titles: – TitleFull: Nature communications Type: main |
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