Structural determinants for GPCR-mediated inhibition of TASK K2P channels by diacylglycerol and its dysfunction in disease.
Saved in:
| Title: | Structural determinants for GPCR-mediated inhibition of TASK K2P channels by diacylglycerol and its dysfunction in disease. |
|---|---|
| Authors: | Jouen-Tachoire TRH; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.; Department of Pharmacology, University of Oxford, Oxford, UK.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK., Proks P; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK., Seiferth D; Department of Biochemistry, University of Oxford, Oxford, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK., Crowther K; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK., Biggin PC; Department of Biochemistry, University of Oxford, Oxford, UK., Baukrowitz T; Institute of Physiology, Kiel University, Kiel, Germany., Schewe M; Institute of Physiology, Kiel University, Kiel, Germany. m.schewe@physiologie.uni-kiel.de., Tucker SJ; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk. |
| Source: | The EMBO journal [EMBO J] 2026 Apr; Vol. 45 (7), pp. 2400-2412. Date of Electronic Publication: 2026 Feb 25. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
|
Full text is not displayed to guests.
Login for full access.
|
|
| ISSN: | 1460-2075 |
|---|---|
| DOI: | 10.1038/s44318-026-00710-6 |
