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Structural determinants for GPCR-mediated inhibition of TASK K2P channels by diacylglycerol and its dysfunction in disease.

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Title: Structural determinants for GPCR-mediated inhibition of TASK K2P channels by diacylglycerol and its dysfunction in disease.
Authors: Jouen-Tachoire TRH; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.; Department of Pharmacology, University of Oxford, Oxford, UK.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK., Proks P; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK., Seiferth D; Department of Biochemistry, University of Oxford, Oxford, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK., Crowther K; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK., Biggin PC; Department of Biochemistry, University of Oxford, Oxford, UK., Baukrowitz T; Institute of Physiology, Kiel University, Kiel, Germany., Schewe M; Institute of Physiology, Kiel University, Kiel, Germany. m.schewe@physiologie.uni-kiel.de., Tucker SJ; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk.
Source: The EMBO journal [EMBO J] 2026 Apr; Vol. 45 (7), pp. 2400-2412. Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Structural determinants for GPCR-mediated inhibition of TASK K2P channels by diacylglycerol and its dysfunction in disease.
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  Data: <searchLink fieldCode="AU" term="%22Jouen-Tachoire+TRH%22">Jouen-Tachoire TRH</searchLink>; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.; Department of Pharmacology, University of Oxford, Oxford, UK.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Proks+P%22">Proks P</searchLink>; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Seiferth+D%22">Seiferth D</searchLink>; Department of Biochemistry, University of Oxford, Oxford, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Crowther+K%22">Crowther K</searchLink>; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Biggin+PC%22">Biggin PC</searchLink>; Department of Biochemistry, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Baukrowitz+T%22">Baukrowitz T</searchLink>; Institute of Physiology, Kiel University, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Schewe+M%22">Schewe M</searchLink>; Institute of Physiology, Kiel University, Kiel, Germany. m.schewe@physiologie.uni-kiel.de.<br /><searchLink fieldCode="AU" term="%22Tucker+SJ%22">Tucker SJ</searchLink>; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk.
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