Microglial serine racemase knockout alleviates Alzheimer-like neuropathology and behavioral deficit via lactylation-mediated anti-inflammation.

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Title: Microglial serine racemase knockout alleviates Alzheimer-like neuropathology and behavioral deficit via lactylation-mediated anti-inflammation.
Authors: Zhou J; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China., Yang Y; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China., Liu S; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China., Chen J; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China., Liao H; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China., Liang W; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China., Zhang Z; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China., Wang Y; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China., Liu Y; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China., Zhang H; Zhejiang Provincial Key Lab for Subtropical Water Environment and Marine Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Wenzhou, China., Jiang H; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China., Lin W; The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People's Hospital of Shenzhen, Shenzhen, China., Qu J; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China., Barger SW; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Wu S; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China. wszlab@wmu.edu.cn.
Source: Communications biology [Commun Biol] 2026 Feb 25; Vol. 9 (1). Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2399-3642
DOI:10.1038/s42003-026-09772-y