Polystyrene microplastic-induced pathophysiology is driven by disruption of efferocytosis.

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Title: Polystyrene microplastic-induced pathophysiology is driven by disruption of efferocytosis.
Authors: Codo AC; Immunology & Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Romero-Pichardo JE; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Wang Z; Immunology & Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Aufiero MA; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Lazarov T; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Saitz Rojas W; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Walker NS; Tri-Institutional Program in Chemical Biology, New York, NY, USA; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Nair A; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Cole RF; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; ACCESS Summer Research Program, Weill Cornell Medicine, New York, NY, USA; University of Central Florida, Orlando, FL, USA., Adkins S; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Dong E; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Fadojutimi K; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Bridge Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Martínez de la Torre C; Department of Radiology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., David Y; Tri-Institutional Program in Chemical Biology, New York, NY, USA; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Department of Physiology, Biophysics, and System Biology, Weill Cornell Medicine, New York, NY, USA., Hohl TM; Immunology & Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Immuno-Oncology, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Infectious Disease Service, Department of Medicine, Memorial Hospital, New York, NY, USA., Geissmann F; Immunology & Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Keshari KR; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Bridge Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Radiology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Lucas CD; University of Edinburgh Centre for Inflammation Research, Edinburgh BioQuarter, UK; Institute for Regeneration and Repair, Edinburgh BioQuarter, UK., Perry JSA; Immunology & Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: perryj@mskcc.org.
Source: Immunity [Immunity] 2026 Mar 10; Vol. 59 (3), pp. 618-636.e11. Date of Electronic Publication: 2026 Feb 24.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4180
DOI:10.1016/j.immuni.2026.01.009