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Identification and Evaluation of dibasic piperidines as novel cell wall inhibitors against Mycobacterium tuberculosis.

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Title: Identification and Evaluation of dibasic piperidines as novel cell wall inhibitors against Mycobacterium tuberculosis.
Authors: Naylor C; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Prosser GA; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Bayliss T; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Berle L; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, 9000 Rockville Pike, Bethesda, Maryland, MD 20892, USA., Wallach JB; Dept. of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA., Kim H; Dept. of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA., Olvera RA; Dept. of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA., Thompson S; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Ioerger TR; Department of Computer Science and Engineering, Texas A&M University, College Station, TX 77843, USA., Simpson L; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Casanueva R; Global Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760, Madrid, Spain., Guijarro-Lopez L; Global Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760, Madrid, Spain., Read KD; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Wyatt PG; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Schnappinger D; Dept. of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA., Barry CE; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, 9000 Rockville Pike, Bethesda, Maryland, MD 20892, USA., Green SR; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Boshoff HI; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, 9000 Rockville Pike, Bethesda, Maryland, MD 20892, USA., Cleghorn LAT; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jan 30. Date of Electronic Publication: 2026 Jan 30.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Identification and Evaluation of dibasic piperidines as novel cell wall inhibitors against Mycobacterium tuberculosis.
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  Data: <searchLink fieldCode="AU" term="%22Naylor+C%22">Naylor C</searchLink>; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.<br /><searchLink fieldCode="AU" term="%22Prosser+GA%22">Prosser GA</searchLink>; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.<br /><searchLink fieldCode="AU" term="%22Bayliss+T%22">Bayliss T</searchLink>; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.<br /><searchLink fieldCode="AU" term="%22Berle+L%22">Berle L</searchLink>; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, 9000 Rockville Pike, Bethesda, Maryland, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Wallach+JB%22">Wallach JB</searchLink>; Dept. of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Kim+H%22">Kim H</searchLink>; Dept. of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Olvera+RA%22">Olvera RA</searchLink>; Dept. of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Thompson+S%22">Thompson S</searchLink>; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.<br /><searchLink fieldCode="AU" term="%22Ioerger+TR%22">Ioerger TR</searchLink>; Department of Computer Science and Engineering, Texas A&M University, College Station, TX 77843, USA.<br /><searchLink fieldCode="AU" term="%22Simpson+L%22">Simpson L</searchLink>; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.<br /><searchLink fieldCode="AU" term="%22Casanueva+R%22">Casanueva R</searchLink>; Global Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Guijarro-Lopez+L%22">Guijarro-Lopez L</searchLink>; Global Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Read+KD%22">Read KD</searchLink>; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.<br /><searchLink fieldCode="AU" term="%22Wyatt+PG%22">Wyatt PG</searchLink>; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.<br /><searchLink fieldCode="AU" term="%22Schnappinger+D%22">Schnappinger D</searchLink>; Dept. of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Barry+CE%22">Barry CE</searchLink>; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, 9000 Rockville Pike, Bethesda, Maryland, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Green+SR%22">Green SR</searchLink>; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.<br /><searchLink fieldCode="AU" term="%22Boshoff+HI%22">Boshoff HI</searchLink>; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, 9000 Rockville Pike, Bethesda, Maryland, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Cleghorn+LAT%22">Cleghorn LAT</searchLink>; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.
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