WBP2 Attenuates Metformin Response in HER2-Positive Breast Cancer Cells by Repressing AMPK Activation and Inducing a Lower AMP:ATP Ratio State Through Enhanced ATP Production.
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| Title: | WBP2 Attenuates Metformin Response in HER2-Positive Breast Cancer Cells by Repressing AMPK Activation and Inducing a Lower AMP:ATP Ratio State Through Enhanced ATP Production. |
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| Authors: | Lin H; School of Medicine, Zhejiang University-University of Edinburgh Institute, Zhejiang University, Hangzhou 314400, China.; Department of Cancer Biology & Innovation, Guoke Ningbo Life Science and Health Industry Research Institute, Ningbo 315000, China.; Integrative Sciences and Engineering Programme, National University of Singapore, Singapore 119077, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore., Kang SA; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore., Xie F; Department of Breast Disease Center, Peking University People's Hospital, Beijing 100044, China., Lim YX; Integrative Sciences and Engineering Programme, National University of Singapore, Singapore 119077, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore., Seah SH; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.; Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore., Sabbaghian A; School of Medicine, Zhejiang University-University of Edinburgh Institute, Zhejiang University, Hangzhou 314400, China.; Department of Cancer Biology & Innovation, Guoke Ningbo Life Science and Health Industry Research Institute, Ningbo 315000, China., Lu SY; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore., Chew TG; School of Medicine, Zhejiang University-University of Edinburgh Institute, Zhejiang University, Hangzhou 314400, China., Deng LW; Integrative Sciences and Engineering Programme, National University of Singapore, Singapore 119077, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.; National University of Singapore's (NUS) Center for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore., Wang S; Department of Breast Disease Center, Peking University People's Hospital, Beijing 100044, China., Tai ES; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore., Lim YP; Department of Cancer Biology & Innovation, Guoke Ningbo Life Science and Health Industry Research Institute, Ningbo 315000, China.; Integrative Sciences and Engineering Programme, National University of Singapore, Singapore 119077, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore. |
| Source: | Cells [Cells] 2026 Feb 23; Vol. 15 (4). Date of Electronic Publication: 2026 Feb 23. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE; In Process |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2073-4409 |
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| DOI: | 10.3390/cells15040381 |
