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WBP2 Attenuates Metformin Response in HER2-Positive Breast Cancer Cells by Repressing AMPK Activation and Inducing a Lower AMP:ATP Ratio State Through Enhanced ATP Production.

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Title: WBP2 Attenuates Metformin Response in HER2-Positive Breast Cancer Cells by Repressing AMPK Activation and Inducing a Lower AMP:ATP Ratio State Through Enhanced ATP Production.
Authors: Lin H; School of Medicine, Zhejiang University-University of Edinburgh Institute, Zhejiang University, Hangzhou 314400, China.; Department of Cancer Biology & Innovation, Guoke Ningbo Life Science and Health Industry Research Institute, Ningbo 315000, China.; Integrative Sciences and Engineering Programme, National University of Singapore, Singapore 119077, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore., Kang SA; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore., Xie F; Department of Breast Disease Center, Peking University People's Hospital, Beijing 100044, China., Lim YX; Integrative Sciences and Engineering Programme, National University of Singapore, Singapore 119077, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore., Seah SH; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.; Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore., Sabbaghian A; School of Medicine, Zhejiang University-University of Edinburgh Institute, Zhejiang University, Hangzhou 314400, China.; Department of Cancer Biology & Innovation, Guoke Ningbo Life Science and Health Industry Research Institute, Ningbo 315000, China., Lu SY; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore., Chew TG; School of Medicine, Zhejiang University-University of Edinburgh Institute, Zhejiang University, Hangzhou 314400, China., Deng LW; Integrative Sciences and Engineering Programme, National University of Singapore, Singapore 119077, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.; National University of Singapore's (NUS) Center for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore., Wang S; Department of Breast Disease Center, Peking University People's Hospital, Beijing 100044, China., Tai ES; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore., Lim YP; Department of Cancer Biology & Innovation, Guoke Ningbo Life Science and Health Industry Research Institute, Ningbo 315000, China.; Integrative Sciences and Engineering Programme, National University of Singapore, Singapore 119077, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.
Source: Cells [Cells] 2026 Feb 23; Vol. 15 (4). Date of Electronic Publication: 2026 Feb 23.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
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  Data: WBP2 Attenuates Metformin Response in HER2-Positive Breast Cancer Cells by Repressing AMPK Activation and Inducing a Lower AMP:ATP Ratio State Through Enhanced ATP Production.
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  Data: <searchLink fieldCode="AU" term="%22Lin+H%22">Lin H</searchLink>; School of Medicine, Zhejiang University-University of Edinburgh Institute, Zhejiang University, Hangzhou 314400, China.; Department of Cancer Biology & Innovation, Guoke Ningbo Life Science and Health Industry Research Institute, Ningbo 315000, China.; Integrative Sciences and Engineering Programme, National University of Singapore, Singapore 119077, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.<br /><searchLink fieldCode="AU" term="%22Kang+SA%22">Kang SA</searchLink>; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.<br /><searchLink fieldCode="AU" term="%22Xie+F%22">Xie F</searchLink>; Department of Breast Disease Center, Peking University People's Hospital, Beijing 100044, China.<br /><searchLink fieldCode="AU" term="%22Lim+YX%22">Lim YX</searchLink>; Integrative Sciences and Engineering Programme, National University of Singapore, Singapore 119077, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.<br /><searchLink fieldCode="AU" term="%22Seah+SH%22">Seah SH</searchLink>; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.; Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore.<br /><searchLink fieldCode="AU" term="%22Sabbaghian+A%22">Sabbaghian A</searchLink>; School of Medicine, Zhejiang University-University of Edinburgh Institute, Zhejiang University, Hangzhou 314400, China.; Department of Cancer Biology & Innovation, Guoke Ningbo Life Science and Health Industry Research Institute, Ningbo 315000, China.<br /><searchLink fieldCode="AU" term="%22Lu+SY%22">Lu SY</searchLink>; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.<br /><searchLink fieldCode="AU" term="%22Chew+TG%22">Chew TG</searchLink>; School of Medicine, Zhejiang University-University of Edinburgh Institute, Zhejiang University, Hangzhou 314400, China.<br /><searchLink fieldCode="AU" term="%22Deng+LW%22">Deng LW</searchLink>; Integrative Sciences and Engineering Programme, National University of Singapore, Singapore 119077, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.; National University of Singapore's (NUS) Center for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Department of Breast Disease Center, Peking University People's Hospital, Beijing 100044, China.<br /><searchLink fieldCode="AU" term="%22Tai+ES%22">Tai ES</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.<br /><searchLink fieldCode="AU" term="%22Lim+YP%22">Lim YP</searchLink>; Department of Cancer Biology & Innovation, Guoke Ningbo Life Science and Health Industry Research Institute, Ningbo 315000, China.; Integrative Sciences and Engineering Programme, National University of Singapore, Singapore 119077, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.
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              Text: 2026 Feb 23
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