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Sensitive CAR T cells redefine targetable CD70 expression in solid tumors.

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Title: Sensitive CAR T cells redefine targetable CD70 expression in solid tumors.
Authors: Hanina SA; Columbia Initiative in Cell Engineering and Therapy (CICET), Department of Medicine, Columbia University Irving Medical Center, Columbia University, New York, NY USA., Park T; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Lopez M; Columbia Initiative in Cell Engineering and Therapy (CICET), Department of Medicine, Columbia University Irving Medical Center, Columbia University, New York, NY USA., Rajasekhar VK; Orthopedic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Mansilla-Soto J; Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Haubner S; Columbia Initiative in Cell Engineering and Therapy (CICET), Department of Medicine, Columbia University Irving Medical Center, Columbia University, New York, NY USA., Zhao H; Antitumor Assessment Core Facility, Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kogel F; Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Nataraj S; Columbia Initiative in Cell Engineering and Therapy (CICET), Department of Medicine, Columbia University Irving Medical Center, Columbia University, New York, NY USA., Banerjee P; Bio-Imaging Resource Center, The Rockefeller University, New York, NY USA., Koche R; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Hamard PJ; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Tarcan ZC; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chi DS; Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY, USA., Zamarin D; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Healey JH; Orthopedic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., de Stanchina E; Antitumor Assessment Core Facility, Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Motzer RJ; Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kotecha RR; Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Hakimi AA; Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Leslie CS; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Sadelain M; Columbia Initiative in Cell Engineering and Therapy (CICET), Department of Medicine, Columbia University Irving Medical Center, Columbia University, New York, NY USA.
Source: Science (New York, N.Y.) [Science] 2026 Feb 26; Vol. 391 (6788), pp. 896-905. Date of Electronic Publication: 2026 Feb 26.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Hanina+SA%22">Hanina SA</searchLink>; Columbia Initiative in Cell Engineering and Therapy (CICET), Department of Medicine, Columbia University Irving Medical Center, Columbia University, New York, NY USA.<br /><searchLink fieldCode="AU" term="%22Park+T%22">Park T</searchLink>; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lopez+M%22">Lopez M</searchLink>; Columbia Initiative in Cell Engineering and Therapy (CICET), Department of Medicine, Columbia University Irving Medical Center, Columbia University, New York, NY USA.<br /><searchLink fieldCode="AU" term="%22Rajasekhar+VK%22">Rajasekhar VK</searchLink>; Orthopedic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Mansilla-Soto+J%22">Mansilla-Soto J</searchLink>; Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Haubner+S%22">Haubner S</searchLink>; Columbia Initiative in Cell Engineering and Therapy (CICET), Department of Medicine, Columbia University Irving Medical Center, Columbia University, New York, NY USA.<br /><searchLink fieldCode="AU" term="%22Zhao+H%22">Zhao H</searchLink>; Antitumor Assessment Core Facility, Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kogel+F%22">Kogel F</searchLink>; Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Nataraj+S%22">Nataraj S</searchLink>; Columbia Initiative in Cell Engineering and Therapy (CICET), Department of Medicine, Columbia University Irving Medical Center, Columbia University, New York, NY USA.<br /><searchLink fieldCode="AU" term="%22Banerjee+P%22">Banerjee P</searchLink>; Bio-Imaging Resource Center, The Rockefeller University, New York, NY USA.<br /><searchLink fieldCode="AU" term="%22Koche+R%22">Koche R</searchLink>; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hamard+PJ%22">Hamard PJ</searchLink>; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Tarcan+ZC%22">Tarcan ZC</searchLink>; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chi+DS%22">Chi DS</searchLink>; Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zamarin+D%22">Zamarin D</searchLink>; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Healey+JH%22">Healey JH</searchLink>; Orthopedic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22de+Stanchina+E%22">de Stanchina E</searchLink>; Antitumor Assessment Core Facility, Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Motzer+RJ%22">Motzer RJ</searchLink>; Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kotecha+RR%22">Kotecha RR</searchLink>; Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hakimi+AA%22">Hakimi AA</searchLink>; Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Leslie+CS%22">Leslie CS</searchLink>; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sadelain+M%22">Sadelain M</searchLink>; Columbia Initiative in Cell Engineering and Therapy (CICET), Department of Medicine, Columbia University Irving Medical Center, Columbia University, New York, NY USA.
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