Effect of intranasal treatment with NAMPT-EVs on acetylated tau and cognitive function in mice with repeated controlled cortical injury.

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Title: Effect of intranasal treatment with NAMPT-EVs on acetylated tau and cognitive function in mice with repeated controlled cortical injury.
Authors: Chen W; Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China., Wu ZC; Extracellular Vesicle Research and Clinical Translational Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China., Lin L; Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China., Huang S; Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China., Jiang Q; Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China., Huang H; Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China., Xie YC; Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, PR China; Extracellular Vesicle Research and Clinical Translational Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China., Huang LX; Extracellular Vesicle Research and Clinical Translational Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China., Li G; Guangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, Guangdong, 510663, PR China., Fu QL; Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, PR China; Extracellular Vesicle Research and Clinical Translational Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China. Electronic address: fuqingl@mail.sysu.edu.cn., Pei Z; Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China. Electronic address: peizhong@mail.sysu.edu.cn., Yao X; Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China. Electronic address: yaoxiaol@mail.sysu.edu.cn.
Source: International immunopharmacology [Int Immunopharmacol] 2026 Apr 15; Vol. 175, pp. 116415. Date of Electronic Publication: 2026 Feb 26.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1878-1705
DOI:10.1016/j.intimp.2026.116415