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Antisense Dipeptide Repeat Proteins Drive Widescale Purine Metabolism Aberration in C9orf72 Amyotrophic Lateral Sclerosis via ADA.

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Title: Antisense Dipeptide Repeat Proteins Drive Widescale Purine Metabolism Aberration in C9orf72 Amyotrophic Lateral Sclerosis via ADA.
Authors: Hall B; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Castelli L; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Higginbottom A; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., He J; Department of Chemistry, The Pennsylvania State University, University Park, State College, PA 16802, USA., Zou LN; Department of Chemistry, The Pennsylvania State University, University Park, State College, PA 16802, USA., Walker H; biOMICS Mass Spectrometry Facility, Alfred Denny Building, Western Bank, University of Sheffield, Sheffield S10 2TN, UK., Yagüe-Capilla M; SciLifeLab, Department of Oncology-Pathology, Karolinska Institutet, 171 64 Stockholm, Sweden., Wong KE; Metabolon Inc., Morrisville, NC 27560, USA., Burrows DJ; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., George J; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Hamer K; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Tanner JM; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Kyrgiou-Balli E; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Ross R; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Garland H; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Tonkiss E; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., George R; biOMICS Mass Spectrometry Facility, Alfred Denny Building, Western Bank, University of Sheffield, Sheffield S10 2TN, UK., Webster CP; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Smith EF; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Timmons HO; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Allsop J; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Stefanidis N; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Ward BD; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Lin YH; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Highley JR; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Azzouz M; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., West RJH; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Rudd SG; SciLifeLab, Department of Oncology-Pathology, Karolinska Institutet, 171 64 Stockholm, Sweden., Vos KJ; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Shaw PJ; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Hautbergue GM; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Allen SP; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Source: International journal of molecular sciences [Int J Mol Sci] 2026 Feb 18; Vol. 27 (4). Date of Electronic Publication: 2026 Feb 18.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
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  Data: Antisense Dipeptide Repeat Proteins Drive Widescale Purine Metabolism Aberration in C9orf72 Amyotrophic Lateral Sclerosis via ADA.
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  Data: <searchLink fieldCode="AU" term="%22Hall+B%22">Hall B</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Castelli+L%22">Castelli L</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Higginbottom+A%22">Higginbottom A</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22He+J%22">He J</searchLink>; Department of Chemistry, The Pennsylvania State University, University Park, State College, PA 16802, USA.<br /><searchLink fieldCode="AU" term="%22Zou+LN%22">Zou LN</searchLink>; Department of Chemistry, The Pennsylvania State University, University Park, State College, PA 16802, USA.<br /><searchLink fieldCode="AU" term="%22Walker+H%22">Walker H</searchLink>; biOMICS Mass Spectrometry Facility, Alfred Denny Building, Western Bank, University of Sheffield, Sheffield S10 2TN, UK.<br /><searchLink fieldCode="AU" term="%22Yagüe-Capilla+M%22">Yagüe-Capilla M</searchLink>; SciLifeLab, Department of Oncology-Pathology, Karolinska Institutet, 171 64 Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Wong+KE%22">Wong KE</searchLink>; Metabolon Inc., Morrisville, NC 27560, USA.<br /><searchLink fieldCode="AU" term="%22Burrows+DJ%22">Burrows DJ</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22George+J%22">George J</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Hamer+K%22">Hamer K</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Tanner+JM%22">Tanner JM</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Kyrgiou-Balli+E%22">Kyrgiou-Balli E</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Ross+R%22">Ross R</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Garland+H%22">Garland H</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Tonkiss+E%22">Tonkiss E</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22George+R%22">George R</searchLink>; biOMICS Mass Spectrometry Facility, Alfred Denny Building, Western Bank, University of Sheffield, Sheffield S10 2TN, UK.<br /><searchLink fieldCode="AU" term="%22Webster+CP%22">Webster CP</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Smith+EF%22">Smith EF</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Timmons+HO%22">Timmons HO</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Allsop+J%22">Allsop J</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Stefanidis+N%22">Stefanidis N</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Ward+BD%22">Ward BD</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Lin+YH%22">Lin YH</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Highley+JR%22">Highley JR</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Azzouz+M%22">Azzouz M</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22West+RJH%22">West RJH</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Rudd+SG%22">Rudd SG</searchLink>; SciLifeLab, Department of Oncology-Pathology, Karolinska Institutet, 171 64 Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Vos+KJ%22">Vos KJ</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Shaw+PJ%22">Shaw PJ</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Hautbergue+GM%22">Hautbergue GM</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Allen+SP%22">Allen SP</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
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