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A Cryptic Pocket Allosterically Modulates Oligosaccharide Binding to DC-SIGN.

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Title: A Cryptic Pocket Allosterically Modulates Oligosaccharide Binding to DC-SIGN.
Authors: Lefèbre J; Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.; Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.; Department of Microbiology, Immunology and Genetics, University of Vienna, Max F. Perutz Laboratories, Dr. Bohr Gasse 9, Vienna 1030, Austria., Besch M; Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.; Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.; Department of Microbiology, Immunology and Genetics, University of Vienna, Max F. Perutz Laboratories, Dr. Bohr Gasse 9, Vienna 1030, Austria., Gamarra MD; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (FCEyN-UBA), Ciudad de Buenos Aires C1428EGA, Argentina.; Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN) CONICET, Pabellón 2 de Ciudad Universitaria, Ciudad de Buenos Aires C1428EHA, Argentina., Kapp-Joswig JO; Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, Arnimallee 22, Berlin 14195, Germany., Balke A; Institute of Medical Physics and Biophysics, Group Structural Biology of Cellular Signaling, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin 10117, Germany., Aleksić S; Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, Arnimallee 22, Berlin 14195, Germany., Flatau H; Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.; Department of Microbiology, Immunology and Genetics, University of Vienna, Max F. Perutz Laboratories, Dr. Bohr Gasse 9, Vienna 1030, Austria., Suchy G; Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.; Department of Microbiology, Immunology and Genetics, University of Vienna, Max F. Perutz Laboratories, Dr. Bohr Gasse 9, Vienna 1030, Austria., Georgieva E; Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, Arnimallee 22, Berlin 14195, Germany., Scheerer P; Institute of Medical Physics and Biophysics, Group Structural Biology of Cellular Signaling, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin 10117, Germany., Keller BG; Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, Arnimallee 22, Berlin 14195, Germany., Modenutti CP; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (FCEyN-UBA), Ciudad de Buenos Aires C1428EGA, Argentina.; Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN) CONICET, Pabellón 2 de Ciudad Universitaria, Ciudad de Buenos Aires C1428EHA, Argentina.; Istituto di Biologia e Biotecnologia Agraria (IBBA), Consiglio Nazionale della Ricerca (CNR), Via Alfonso Corti nr. 12, Milano 20133, Italia., Rademacher C; Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.; Department of Microbiology, Immunology and Genetics, University of Vienna, Max F. Perutz Laboratories, Dr. Bohr Gasse 9, Vienna 1030, Austria.
Source: JACS Au [JACS Au] 2026 Jan 20; Vol. 6 (2), pp. 1048-1060. Date of Electronic Publication: 2026 Jan 20 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101775714 Publication Model: eCollection Cited Medium: Internet ISSN: 2691-3704 (Electronic) Linking ISSN: 26913704 NLM ISO Abbreviation: JACS Au Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Lefèbre+J%22">Lefèbre J</searchLink>; Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.; Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.; Department of Microbiology, Immunology and Genetics, University of Vienna, Max F. Perutz Laboratories, Dr. Bohr Gasse 9, Vienna 1030, Austria.<br /><searchLink fieldCode="AU" term="%22Besch+M%22">Besch M</searchLink>; Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.; Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.; Department of Microbiology, Immunology and Genetics, University of Vienna, Max F. Perutz Laboratories, Dr. Bohr Gasse 9, Vienna 1030, Austria.<br /><searchLink fieldCode="AU" term="%22Gamarra+MD%22">Gamarra MD</searchLink>; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (FCEyN-UBA), Ciudad de Buenos Aires C1428EGA, Argentina.; Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN) CONICET, Pabellón 2 de Ciudad Universitaria, Ciudad de Buenos Aires C1428EHA, Argentina.<br /><searchLink fieldCode="AU" term="%22Kapp-Joswig+JO%22">Kapp-Joswig JO</searchLink>; Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, Arnimallee 22, Berlin 14195, Germany.<br /><searchLink fieldCode="AU" term="%22Balke+A%22">Balke A</searchLink>; Institute of Medical Physics and Biophysics, Group Structural Biology of Cellular Signaling, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin 10117, Germany.<br /><searchLink fieldCode="AU" term="%22Aleksić+S%22">Aleksić S</searchLink>; Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, Arnimallee 22, Berlin 14195, Germany.<br /><searchLink fieldCode="AU" term="%22Flatau+H%22">Flatau H</searchLink>; Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.; Department of Microbiology, Immunology and Genetics, University of Vienna, Max F. Perutz Laboratories, Dr. Bohr Gasse 9, Vienna 1030, Austria.<br /><searchLink fieldCode="AU" term="%22Suchy+G%22">Suchy G</searchLink>; Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.; Department of Microbiology, Immunology and Genetics, University of Vienna, Max F. Perutz Laboratories, Dr. Bohr Gasse 9, Vienna 1030, Austria.<br /><searchLink fieldCode="AU" term="%22Georgieva+E%22">Georgieva E</searchLink>; Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, Arnimallee 22, Berlin 14195, Germany.<br /><searchLink fieldCode="AU" term="%22Scheerer+P%22">Scheerer P</searchLink>; Institute of Medical Physics and Biophysics, Group Structural Biology of Cellular Signaling, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin 10117, Germany.<br /><searchLink fieldCode="AU" term="%22Keller+BG%22">Keller BG</searchLink>; Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, Arnimallee 22, Berlin 14195, Germany.<br /><searchLink fieldCode="AU" term="%22Modenutti+CP%22">Modenutti CP</searchLink>; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (FCEyN-UBA), Ciudad de Buenos Aires C1428EGA, Argentina.; Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN) CONICET, Pabellón 2 de Ciudad Universitaria, Ciudad de Buenos Aires C1428EHA, Argentina.; Istituto di Biologia e Biotecnologia Agraria (IBBA), Consiglio Nazionale della Ricerca (CNR), Via Alfonso Corti nr. 12, Milano 20133, Italia.<br /><searchLink fieldCode="AU" term="%22Rademacher+C%22">Rademacher C</searchLink>; Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.; Department of Microbiology, Immunology and Genetics, University of Vienna, Max F. Perutz Laboratories, Dr. Bohr Gasse 9, Vienna 1030, Austria.
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