Pharmacological Inhibition of SLC33A1 Promotes Endoplasmic Reticulum Hyperoxidation and Induces Adaptive IRE1/XBP1s Signaling.

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Title: Pharmacological Inhibition of SLC33A1 Promotes Endoplasmic Reticulum Hyperoxidation and Induces Adaptive IRE1/XBP1s Signaling.
Authors: Kutseikin S; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA., Rafiq M; Department of Integrative Computational and Structural Biology, The Scripps Research Institute, La Jolla, CA.; These authors contributed equally to this work., Bora P; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA.; These authors contributed equally to this work., Liu S; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA., Homan RA; Department of Chemistry, The Scripps Research Institute, La Jolla, CA., Mindrebo JT; Department of Integrative Computational and Structural Biology, The Scripps Research Institute, La Jolla, CA., Holcomb M; Department of Integrative Computational and Structural Biology, The Scripps Research Institute, La Jolla, CA., Petrassi HM; Protego Biopharma, San Diego, CA., Qiu H; Protego Biopharma, San Diego, CA., Redkina A; Protego Biopharma, San Diego, CA., Sosna J; Protego Biopharma, San Diego, CA., Lee TT; Protego Biopharma, San Diego, CA., Hu X; Protego Biopharma, San Diego, CA., Forli S; Department of Integrative Computational and Structural Biology, The Scripps Research Institute, La Jolla, CA., Parker CG; Department of Chemistry, The Scripps Research Institute, La Jolla, CA., Lander GC; Department of Integrative Computational and Structural Biology, The Scripps Research Institute, La Jolla, CA., Birsoy K; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA., Saez E; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA., Wiseman RL; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Feb 18. Date of Electronic Publication: 2026 Feb 18.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.64898/2026.02.17.706344