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Pharmacological Inhibition of SLC33A1 Promotes Endoplasmic Reticulum Hyperoxidation and Induces Adaptive IRE1/XBP1s Signaling.

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Title: Pharmacological Inhibition of SLC33A1 Promotes Endoplasmic Reticulum Hyperoxidation and Induces Adaptive IRE1/XBP1s Signaling.
Authors: Kutseikin S; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA., Rafiq M; Department of Integrative Computational and Structural Biology, The Scripps Research Institute, La Jolla, CA.; These authors contributed equally to this work., Bora P; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA.; These authors contributed equally to this work., Liu S; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA., Homan RA; Department of Chemistry, The Scripps Research Institute, La Jolla, CA., Mindrebo JT; Department of Integrative Computational and Structural Biology, The Scripps Research Institute, La Jolla, CA., Holcomb M; Department of Integrative Computational and Structural Biology, The Scripps Research Institute, La Jolla, CA., Petrassi HM; Protego Biopharma, San Diego, CA., Qiu H; Protego Biopharma, San Diego, CA., Redkina A; Protego Biopharma, San Diego, CA., Sosna J; Protego Biopharma, San Diego, CA., Lee TT; Protego Biopharma, San Diego, CA., Hu X; Protego Biopharma, San Diego, CA., Forli S; Department of Integrative Computational and Structural Biology, The Scripps Research Institute, La Jolla, CA., Parker CG; Department of Chemistry, The Scripps Research Institute, La Jolla, CA., Lander GC; Department of Integrative Computational and Structural Biology, The Scripps Research Institute, La Jolla, CA., Birsoy K; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA., Saez E; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA., Wiseman RL; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Feb 18. Date of Electronic Publication: 2026 Feb 18.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Pharmacological Inhibition of SLC33A1 Promotes Endoplasmic Reticulum Hyperoxidation and Induces Adaptive IRE1/XBP1s Signaling.
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  Data: <searchLink fieldCode="AU" term="%22Kutseikin+S%22">Kutseikin S</searchLink>; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA.<br /><searchLink fieldCode="AU" term="%22Rafiq+M%22">Rafiq M</searchLink>; Department of Integrative Computational and Structural Biology, The Scripps Research Institute, La Jolla, CA.; These authors contributed equally to this work.<br /><searchLink fieldCode="AU" term="%22Bora+P%22">Bora P</searchLink>; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA.; These authors contributed equally to this work.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Homan+RA%22">Homan RA</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, CA.<br /><searchLink fieldCode="AU" term="%22Mindrebo+JT%22">Mindrebo JT</searchLink>; Department of Integrative Computational and Structural Biology, The Scripps Research Institute, La Jolla, CA.<br /><searchLink fieldCode="AU" term="%22Holcomb+M%22">Holcomb M</searchLink>; Department of Integrative Computational and Structural Biology, The Scripps Research Institute, La Jolla, CA.<br /><searchLink fieldCode="AU" term="%22Petrassi+HM%22">Petrassi HM</searchLink>; Protego Biopharma, San Diego, CA.<br /><searchLink fieldCode="AU" term="%22Qiu+H%22">Qiu H</searchLink>; Protego Biopharma, San Diego, CA.<br /><searchLink fieldCode="AU" term="%22Redkina+A%22">Redkina A</searchLink>; Protego Biopharma, San Diego, CA.<br /><searchLink fieldCode="AU" term="%22Sosna+J%22">Sosna J</searchLink>; Protego Biopharma, San Diego, CA.<br /><searchLink fieldCode="AU" term="%22Lee+TT%22">Lee TT</searchLink>; Protego Biopharma, San Diego, CA.<br /><searchLink fieldCode="AU" term="%22Hu+X%22">Hu X</searchLink>; Protego Biopharma, San Diego, CA.<br /><searchLink fieldCode="AU" term="%22Forli+S%22">Forli S</searchLink>; Department of Integrative Computational and Structural Biology, The Scripps Research Institute, La Jolla, CA.<br /><searchLink fieldCode="AU" term="%22Parker+CG%22">Parker CG</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, CA.<br /><searchLink fieldCode="AU" term="%22Lander+GC%22">Lander GC</searchLink>; Department of Integrative Computational and Structural Biology, The Scripps Research Institute, La Jolla, CA.<br /><searchLink fieldCode="AU" term="%22Birsoy+K%22">Birsoy K</searchLink>; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Saez+E%22">Saez E</searchLink>; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA.<br /><searchLink fieldCode="AU" term="%22Wiseman+RL%22">Wiseman RL</searchLink>; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA.
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